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Table 3 Comparison of significant features from unsupervised clustering models between derivation and replication cohort

From: A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes

Lipid/oxidative marker at enrollment

Median (25th, 75th)

Derivation cohort

Replication cohort

Hypolipoprotein cluster (n = 58)

Normolipoprotein cluster (n = 110)

p Value+

Hypolipoprotein cluster (n = 26)

Normolipoprotein cluster (n = 60)

p Value^

Total cholesterol (mg/dL)

67 (53, 84)

108 (81, 122)

 < 0.001

87 (70, 102)

101 (82, 133)

0.047

HDL-C (mg/dL)

7 (5, 16)

26 (16, 33)

 < 0.001

10 (5, 30)

34 (20, 46)

 < 0.001

LDL-C (mg/dL)

30 (19, 44)

52 (36, 68)

0.001

41 (29, 68)

46 (35, 66)

0.267

PON-1 (mg/dL)

35.81 (22.4, 67.87)

65.99 (40.03, 114.6)

0.001

46.77 (23.59, 104.98)

89.42 (43.49, 128.59)

0.017

ApoA-I (ng/mL)

754,631 (583,580, 952,226)

1,400,000 (1,000,000, 1,625,000)

 < 0.001

475785 (185360, 763480)

793130 (658255, 1030550)

 < 0.001

ICAM-1 (ng/mL)

589.75 (455.82, 750.58)

346.502 (271.251, 485.513)

 < 0.001

649.15 (516.80, 929.30)

351.92 (222.79, 384.97)

 < 0.001

Cardiovascular SOFA

1 (1, 3)

1 (0, 1)

 < 0.001

2 (0, 4)

1 (0, 3)

0.172

Neurologic SOFA

2 (0, 3)

0 (0, 2)

0.003

0 (0, 2)

2 (0, 3)

0.020

Coagulation SOFA

0 (0, 1)

0 (0, 1)

0.165

1 (0, 2)

0 (0, 1)

0.005

Hepatic SOFA

0 (0, 1)

0 (0, 0)

0.019

2 (1, 2)

0 (0, 0)

 < 0.001

Renal SOFA

2 (0, 3)

1 (0, 2)

0.018

1 (0, 1)

1 (1, 3)

0.190

Respiratory SOFA

2 (0, 3)

0 (0, 2)

0.005

1 (0, 3)

2 (1, 3)

0.007

Systolic BP (mm Hg)

97 (88.25, 114)

113 (100.5, 126.75)

 < 0.001

101 (92, 111)

108 (97, 123)

0.079

Temperature (ËšF)

98.6 (98.1, 99.8)

99.6 (98.6, 101.3)

0.003

99.0 (97.6, 100.2)

99.4 (98.4, 100.5)

0.296

Total SOFA score

8 (6, 10)

4 (2, 6)

 < 0.001

7 (5, 12)

7 (5, 10)

0.741

  1. Bold values are significant after Bonferroni correction for multiple comparisons
  2. Comparisons made using Wilcoxon rank-sum test; +after Bonferroni adjustment for multiple tests, significant if < 0.001 (0.05/47 tests). ^For the replication cohort, after Bonferroni adjustment for multiple tests, significant if p-values < 0.003 (0.05/15 tests) were considered significant. Comparisons are bivariate between Hypolipoprotein and Normolipoprotein Clusters separately for derivation and validation cohorts
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