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Table 3 Outcome at 12 months follow up

From: Comprehensive versus standard care in post-severe acute kidney injury survivors, a randomized controlled trial

Parameters

Comprehensive care

Standard care

p value

Serum creatinine (mg/dL)*

1.14 (0.80,1.46)

1.05 (0.84,2.08)

0.49

eGFR (mL/min/1.73 m2)*

66.74 (30.77)

61.23(35.16)

0.54

UACR (mg/g)*

36.83 (13.39,131.90)

177.70 (47.12,745.71)

0.036

MAKE 365, n (%)a

13/40 (32.5%)

11/38 (28.9%)

0.73

Death, n (%)

7/40 (17.1%)

5/38 (12.8%)

0.59

RRT, n (%)

6/33 (18.2%)

3/33 (9.1%)

0.28

Doubling serum creatinine, n (%)

1/33 (3.0%)

4/33 (12.1%)

0.36

Renal recovery, n (%)b

8/16 (50%)

4/11 (36.4%)

0.70

New RRT, n (%)c

1/28 (3.6%)

2/31 (6.5%)

0.62

New CKD, n (%)d

3/22 (13.6%)

4/19 (21.1%)

0.69

CKD progression, n (%)e

7/11 (63.6%)

11/14 (78.6%)

0.41

Progression of albuminuria, n(%)f

2/33 (6.1%)

6/33 (18.2%)

0.26

Recurrent AKI, n (%)g

6/33 (18.2%)

6/33 (18.2%)

1.00

Readmission, n (%)h

27/49 (55.1%)

24/49 (49%)

0.54

Blood pressure control, n (%)i

29/33 (87.9%)

19/33 (57.6%)

0.006

RAAS inhibitor use, n (%)

18/33 (54.5%)

14/33 (42.4%)

0.33

24-h urine sodium (mmol)

112.82 (63.17)

127.69 (54.23)

0.35

24-h dietary protein intake (g/kg/d)

1.01 (0.32)

0.85 (0.28)

0.07

Albumin (g/dL)

4.1 (3.8,4.4)

4.0 (3.8,4.4)

0.59

EQ-5D-5L index scoresj

0.96 (0.90,1.00)

0.99 (0.80,1.00)

0.80

  1. Significant values are shown in bold type, *Data excluded patients with RRT
  2. AKI, acute kidney injury; CKD, chronic kidney disease; GFR, glomerular filtration rate; RAAS, renin–angiotensin–aldosterone-system; RRT, Renal replacement therapy; SD, standard deviation; UACR, urine albumin creatinine ratio
  3. aMAKE 365; major adverse kidney events at 365 d were comprised of death, incident dialysis (requirement for CRRT), and persistent renal dysfunction death (doubling of serum creatinine or eGFR < 50% from baseline)
  4. bRenal recovery; serum creatinine level had returned to baseline or < 1.5 times from baseline and not ongoing need for RRT or currently receiving RRT (only patients who were non-recovery at discharge)
  5. cNew RRT; new case of RRT
  6. dNew CKD; newly diagnosis of chronic kidney disease by eGFR criteria in no previous history of CKD
  7. eCKD progression; change of staging of CKD by eGFR criteria in previous history of chronic kidney disease
  8. fProgression of albuminuria; change in staging of albuminuria criteria from at 3 months to 12 months post-discharge
  9. gRecurrent AKI; document of AKI definition by KDIGO 2012 criteria
  10. hReadmission; episode of unplanned readmission
  11. iBlood pressure control; blood pressure < 140/90 mmHg in non-hypertensive patients or < 130/80 mmHg in hypertensive patients
  12. jEQ-5D-5L index scores; descriptive system for health-related quality of life states in adults, consisting of five dimensions (Mobility, self-care, usual activities, pain and discomfort and anxiety and depression)
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