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Table 2 Logistic regression analysis for prediction of hospital mortality

From: Elevated HbA1c remains a predominant finding in severe COVID-19 and may be associated with increased mortality in patients requiring mechanical ventilation

 

Univariate analysis

Multivariate analysis

OR (95% CI)

p

OR (95% CI)

p

Age

1.08 (1.05–1.11)

 < 0.001

1.07 (1.04–1.11)

 < 0.001

Sex (male)

1.29 (0.77–2.21)

0.350

  

BMI

1.00 (0.97–1.05)

0.737

  

Number of comorbidities

1.29 (1.13–1.49)

 < 0.001

1.24 (1.04–1.48)

0.018

SAPS III score

1.08 (1.05–1.11)

 < 0.001

1.05 (1.02–1.08)

0.001

IMV

3.08 (1.87–5.21)

 < 0.001

  

Ref: HbA1c < 6.5 and no history of DM

    

HbA1c < 6.5 and history of DM

0.43 (0.20–1.35)

0.194

  

HbA1c ≥ 6.5 and no history of DM

1.05 (0.52–2.05)

0.883

  

HbA1c ≥ 6.5 and history of DM

1.30 (0.75–2.23)

0.346

  

Ref: HbA1c < 6.5 and no history of DM and no IMV

    

HbA1c < 6.5 and history of DM, no IMV

  

0.30 (0.01–2.16)

0.304

HbA1c ≥ 6.5 and no history of DM, no IMV

  

0.31 (0.02–1.99)

0.298

HbA1c ≥ 6.5 and history of DM, no IMV

  

2.18 (0.71–6.71)

0.168

HbA1c < 6.5 and no history of DM, IMV

  

3.94 (1.72–9.66)

0.002

HbA1c < 6.5 and history of DM, IMV

  

0.78 (0.04–6.16)

0.832

HbA1c ≥ 6.5 and no history of DM, IMV

  

6.36 (2.02–20.85)

0.002

HbA1c ≥ 6.5 and history of DM, IMV

  

3.66 (1.38–10.17)

0.011

  1. HbA1c and variables with a p value < 0.05 in univariate analysis were included in multivariate analysis. Of 350 included patients, 44 have been previously reported [1]
  2. BMI body mass index, SAPS simplified acute physiology score, IMV invasive mechanical ventilation, HbA1c glycated hemoglobin, DM diabetes mellitus, OR odds ratio, CI confidence interval, Ref reference category