Table 3 Pooled baseline arterial blood gas and ventilator parameters with mean difference comparison
Parameter | Pooled estimate (95% CI) | p value | ||
|---|---|---|---|---|
Pre-PP | Post-PP | Mean difference | ||
PaO2 | 5 studies | 5 studies | 5 studies | 0.10 |
69.4 [63.3–75.4] | 75.7 [65.2–86.3] |  + 5.1 [− 1.0 to + 11.2] | ||
PaCO2 | 6 studies | 5 studies | 5 studies | 0.03 |
44.7 [42.2–47.2] | 43.7 [41.2–46.2] |  − 1.5 [− 2.9 to − 0.2] | ||
pH | 5 studies | 4 studies | 4 studies | 0.98 |
7.42 [7.41–7.43] | 7.41 [7.40–7.43] |  + 0.0001 [− 0.01 to + 0.01] | ||
PF ratio | 8 studies | 7 studies | 7 studies | 0.01 |
112.2 [92.2–132.3] | 147.7 [131.4–164.0] |  + 24.9 [+ 6.5 to + 43.2] | ||
Tidal volume | 4 studies | 4 studies | 4 studies | 0.21 |
3.2 [2.2–4.1] | 3.7 [2.2–5.2] |  + 0.3 [− 0.2 to + 0.9] | ||
Respiratory rate | 7 studies | 6 studies | 6 studies | 0.08 |
14.7 [13.0–16.4] | 14.3 [11.8–16.7] |  − 0.9 [− 2.0 to + 0.1] | ||
Driving pressure | 3 studies | 3 studies | 3 studies | 0.01 |
11.5 [9.9–13.1] | 10.7 [9.2–12.1] |  − 0.8 [− 1.5 to − 0.2] | ||
Plateau pressure | 5 studies | 4 studies | 4 studies | 0.82 |
26.2 [24.5–28.0] | 27.1 [24.9–29.3] |  − 0.1 [− 1.0 to + 0.8] | ||
PEEP | 7 studies | 6 studies | 6 studies | 0.88 |
14.7 [13.8–15.6] | 15.0 [13.7–16.4] | 0.1 [− 0.9 to + 1.0] | ||
Sweep gas flow | 7 studies | 5 studies | 5 studies | 0.79 |
6.0 [5.3–6.7] | 6.5 [5.9–7.1] |  + 0.1 [− 0.3 to + 0.5] | ||
Respiratory system compliance | 6 studies | 6 studies | 6 studies | 0.12 |
22.0 [20.5–23.6] | 23.8 [21.3–26.3] |  + 1.8 [− 0.5 to + 4.0] | ||