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Table 1 Characteristics of the clinical randomized clinical studies comparing hypothermia at 33 °C with standard of care (i.e., no temperature control or normothermia) or 36 °C targets. For continuous variables, data are presented as mean \(\pm\) SD or median (IQRs), as available in the main manuscript

From: Targeted temperature management and cardiac arrest after the TTM-2 study

  Dankiewicz et al. [5] HACA group [2] Bernard et al. [1] Nielsen et al. [7] Lascarrou et al. [4]
Design Multicentric Multicentric Single-Centre Multicentric Multicentric
N (HT group) 1861 (930) 275 (138)* 79 (43)** 939 (473) 584 (284)
Age, years 64 ± 13 59 (49–67) 67 (49–89) 64 ± 12 67 (57–76)
Male gender 80% 77% 58% 83% 65%
OHCA 100% 100% 100% 100% 74%
Bystander CPR 82% 49% 49% 73% 70%
Shockable rhythm 72% 96% 100% 79% 0%
Time to ROSC, min 25 (16–40) 22 (17–33)* 27 ± 13 25 (18–40) 18 (10–25)
Cause of Arrest Cardiac/UNK Cardiac Cardiac Cardiac/UNK All**
Shock on Admission 28% 49* NR 15% 56%
STEMI on Admission 41% NR NR 40% 16%
Lactate, mmol/L 5.9 ± 4.4 NR 8.3 (2.2–14.9) 6.7 ± 4.5 5.8 (3.2–9.0)
Outcome Assessment 6 months 6 months Hospital Discharge 6 months 3 months
Mortality, %* 50% 41% 51% 50% 81%
UO Assessment Scale mRS 4–6 CPC 3–5 CPC 3–5 CPC 3–5 CPC 3–5
UO, % 55 45 51 54 90
Prognostication Rules Present Absent Absent Present Present
Generalisability/Bias High/low Low/high Low/high High/low High/moderate
  1. HACA, Hypothermia After Cardiac Arrest; N, total number of included patients; HT, hypothermia; OHCA, out-of-hospital cardiac arrest; CPR, cardiopulmonary resuscitation; ROSC, return of spontaneous circulation; min, minutes, UNK, unknown; STEMI; ST-elevation myocardial infarction; UO, unfavorable neurological outcome; mRS, modified Rankin scale; CPC, Cerebral Performance Category
  2. *In the hypothermia group
  3. **Mainly respiratory causes