Table 1 Characteristics of the clinical randomized clinical studies comparing hypothermia at 33 °C with standard of care (i.e., no temperature control or normothermia) or 36 °C targets. For continuous variables, data are presented as mean \(\pm\) SD or median (IQRs), as available in the main manuscript
From: Targeted temperature management and cardiac arrest after the TTM-2 study
Dankiewicz et al. [5] | HACA group [2] | Bernard et al. [1] | Nielsen et al. [7] | Lascarrou et al. [4] | |
|---|---|---|---|---|---|
Design | Multicentric | Multicentric | Single-Centre | Multicentric | Multicentric |
N (HT group) | 1861 (930) | 275 (138)* | 79 (43)** | 939 (473) | 584 (284) |
Age, years | 64 ± 13 | 59 (49–67) | 67 (49–89) | 64 ± 12 | 67 (57–76) |
Male gender | 80% | 77% | 58% | 83% | 65% |
OHCA | 100% | 100% | 100% | 100% | 74% |
Bystander CPR | 82% | 49% | 49% | 73% | 70% |
Shockable rhythm | 72% | 96% | 100% | 79% | 0% |
Time to ROSC, min | 25 (16–40) | 22 (17–33)* | 27 ± 13 | 25 (18–40) | 18 (10–25) |
Cause of Arrest | Cardiac/UNK | Cardiac | Cardiac | Cardiac/UNK | All** |
Shock on Admission | 28% | 49* | NR | 15% | 56% |
STEMI on Admission | 41% | NR | NR | 40% | 16% |
Lactate, mmol/L | 5.9 ± 4.4 | NR | 8.3 (2.2–14.9) | 6.7 ± 4.5 | 5.8 (3.2–9.0) |
Outcome Assessment | 6 months | 6 months | Hospital Discharge | 6 months | 3 months |
Mortality, %* | 50% | 41% | 51% | 50% | 81% |
UO Assessment Scale | mRS 4–6 | CPC 3–5 | CPC 3–5 | CPC 3–5 | CPC 3–5 |
UO, % | 55 | 45 | 51 | 54 | 90 |
Prognostication Rules | Present | Absent | Absent | Present | Present |
Generalisability/Bias | High/low | Low/high | Low/high | High/low | High/moderate |