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Table 4 Clinical predictive value of respiratory variability

From: Breathing variability—implications for anaesthesiology and intensive care

Setting Reference Respiratory measurements Measure of variability  
Preterm infants Usemann et al. [45] Full face mask, flowmeter CV With versus without later hospitalization due to respiratory disease:
TV 0.07 ± 0.03 versus 0.09 ± 0.03*
For each IQR increase in CVVT, OR for rehospitalization increased by 2.25
ICU weaning trial with 5 cmH2O PSV plus 5 cmH2O PEEP Bien et al. [58] Ventilator CV Weaning failure versus weaning success:
TV 0.18 ± 0.09 versus 0.28 ± 0.15*
BT 0.20 ± 0.12 versus 0.31 ± 0.15*
PIF 0.10 ± 0.05 versus 0.16 ± 0.06*
AUC:
TV 0.75 ± 0.06
PIF 0.80 ± 0.05
ICU spontaneous breathing trial without ventilatory support Wysocki et al. [59] Ventilator CV Extubation failure versus extubation success:
TV 0.18 (0.10–0.24) versus 0.25 (0.14–0.51)*
BT 0.14 (0.10–0.21) versus 0.20 (0.13–0.53)*
ICU weaning trial, CPAP 5 cmH2O El Khatib et al. [60] Ventilator CV Extubation failure versus extubation success:
TV 0.26 ± 0.07 versus 0.09 ± 0.04*
PIF 0.30 ± 0.12 versus 0.12 ± 0.04*
    Kolmogorov entropy Extubation failure versus extubation success:
0.39 ± 0.09 versus 0.09 ± 0.03*
    Dimension 3.39 ± 0.47 versus 1.33 ± 0.07*
ICU weaning trial with 12 ± 4.6 cmH2O PSV plus 5 cmH2O PEEP Engeron [61] Ventilator ApEn Extubation failure versus extubation success:
TV 0.328 ± 0.049 versus 0.185 ± 0.027*
RR 0.454 ± 0.022 versus 0.459 ± 0.013
AUC:
TV 0.74 ± 0.07
  1. CV coefficient of variation, TV tidal volume, IQR interquartile range, OR odds ratio, ICU intensive care unit, PSV pressure support ventilation, PEEP positive end-expiratory pressure, BT breathing time, PIF peak inspiratory flow, AUC area under the curve, ApEn approximate entropy*P < 0.05