Table 4 Clinical predictive value of respiratory variability

Preterm infants

Usemann et al. [45]

Full face mask, flowmeter

CV

With versus without later hospitalization due to respiratory disease:

TV 0.07 ± 0.03 versus 0.09 ± 0.03*

For each IQR increase in CV_VT, OR for rehospitalization increased by 2.25

ICU weaning trial with 5 cmH₂O PSV plus 5 cmH₂O PEEP

Bien et al. [58]

Ventilator

CV

Weaning failure versus weaning success:

TV 0.18 ± 0.09 versus 0.28 ± 0.15*

BT 0.20 ± 0.12 versus 0.31 ± 0.15*

PIF 0.10 ± 0.05 versus 0.16 ± 0.06*

AUC:

TV 0.75 ± 0.06

PIF 0.80 ± 0.05

ICU spontaneous breathing trial without ventilatory support

Wysocki et al. [59]

Ventilator

CV

Extubation failure versus extubation success:

TV 0.18 (0.10–0.24) versus 0.25 (0.14–0.51)*

BT 0.14 (0.10–0.21) versus 0.20 (0.13–0.53)*

ICU weaning trial, CPAP 5 cmH₂O

El Khatib et al. [60]

Ventilator

CV

Extubation failure versus extubation success:

TV 0.26 ± 0.07 versus 0.09 ± 0.04*

PIF 0.30 ± 0.12 versus 0.12 ± 0.04*

Kolmogorov entropy

Extubation failure versus extubation success:

0.39 ± 0.09 versus 0.09 ± 0.03*

Dimension

3.39 ± 0.47 versus 1.33 ± 0.07*

ICU weaning trial with 12 ± 4.6 cmH₂O PSV plus 5 cmH₂O PEEP

Engeron [61]

Ventilator

ApEn

Extubation failure versus extubation success:

TV 0.328 ± 0.049 versus 0.185 ± 0.027*

RR 0.454 ± 0.022 versus 0.459 ± 0.013

AUC:

TV 0.74 ± 0.07