Table 1 Baseline demographics and clinical characteristics in ASPECT-NP participants with ventilated hospital-acquired bacterial pneumonia (ITT population). Prognostic factors expected to lead to worse clinical outcomes are in bold text
C/T (N = 99) | Meropenem (N = 108) | Total (N = 207) | |
|---|---|---|---|
Sex | |||
Male, n (%) | 74 (74.7) | 72 (66.7) | 146 (70.5) |
Female, n (%) | 25 (25.3) | 36 (33.3) | 61 (29.5) |
Age, years | |||
< 65, n (%) | 52 (52.5) | 47 (43.5) | 99 (47.8) |
≥ 65, n (%) | 47 (47.5) | 61 (56.5) | 108 (52.2) |
Mean (standard deviation) | 63.3 (15.0) | 65.3 (14.7) | 64.3 (14.9) |
Median (range) | 64.0 (18, 98) | 66.5 (24, 92) | 65.0 (18, 98) |
Weight, kg | |||
Median (range) | 78.1 (34.0, 140.0) | 75.0 (40.0, 151.0) | 78.0 (34.0, 151.0) |
Body-mass index, kg | |||
Median (range) | 26.2 (15.1, 44.1) | 26.1 (15.5, 49.3) | 26.1 (15.1, 49.3) |
Creatinine clearance (mL/min) | |||
≥ 150 (augmented renal clearance), n (%) | 9 (9.1) | 5 (4.6) | 14 (6.8) |
≥ 80, n (%) | 44 (44.4) | 48 (44.4) | 92 (44.4) |
< 80 to > 50, n (%) | 26 (26.3) | 34 (31.5) | 60 (29.0) |
≤ 50 to ≥ 30, n (%) | 17 (17.2) | 10 (9.3) | 27 (13.0) |
< 30 to ≥ 15, n (%) | 12 (12.1) | 13 (12.0) | 25 (12.1) |
< 15 (end-stage renal disease), n (%) | 0 | 0 | 0 |
Missing, n (%) | 0 | 3 (2.8) | 3 (1.4) |
In the ICU | |||
Yes, n (%) | 83 (83.8) | 86 (79.6) | 169 (81.6) |
No, n (%) | 16 (16.2) | 22 (20.4) | 38 (18.4) |
APACHE II score | |||
≤ 14, n (%) | 32 (32.3) | 27 (25.0) | 59 (28.5) |
15–19, n (%) | 36 (36.4) | 40 (37.0) | 76 (36.7) |
≥ 20, n (%) | 31 (31.3) | 40 (37.0) | 71 (34.3) |
Missing, n (%) | 0 | 1 (0.9) | 1 (0.5) |
Mean (standard deviation) | 17.5 (6.1) | 18.4 (5.9) | 18.0 (6.0) |
Median (range) | 16.0 (4, 33) | 17.0 (5, 38) | 17.0 (4, 38) |
SOFA score | |||
≤ 7, n (%) | 57 (57.6) | 65 (60.2) | 122 (58.9) |
> 7, n (%) | 42 (42.4) | 41 (38.0) | 83 (40.1) |
Missing, n (%) | 0 | 2 (1.9) | 2 (1.0) |
Mean (standard deviation) | 7.2 (2.7) | 7.1 (2.7) | 7.1 (2.7) |
Median (range) | 7 (0, 13) | 7 (1, 15) | 7 (0, 15) |
Prior non-study gram-negative therapy* | |||
Yes, n (%) | 92 (92.9) | 93 (86.1) | 185 (89.4) |
No, n (%) | 7 (7.1) | 15 (13.9) | 22 (10.6) |
Failed prior antibacterial therapy for NP | |||
Yes, n (%) | 20 (20.2) | 17 (15.7) | 37 (17.9) |
No, n (%) | 79 (79.8) | 90 (83.3) | 169 (81.6) |
Missing, n (%) | 0 | 1 (0.9) | 1 (0.5) |
Adjunctive gram-negative therapy§ | |||
Yes, n (%) | 35 (35.4) | 34 (31.5) | 69 (33.3) |
No, n (%) | 64 (64.6) | 70 (64.8) | 134 (64.7) |
Missing, n (%) | 0 | 4 (3.7) | 4 (1.9) |
CPIS | |||
≤ 6, n (%) | 9 (9.1) | 7 (6.5) | 16 (7.7) |
7, n (%) | 12 (12.1) | 7 (6.5) | 19 (9.2) |
8, n (%) | 13 (13.1) | 13 (12.0) | 26 (12.6) |
> 8, n (%) | 65 (65.7) | 80 (74.1) | 145 (70.0) |
Missing, n (%) | 0 | 1 (0.9) | 1 (0.5) |
Duration of prior hospitalization† | |||
< 5 days, n (%) | 27 (27.3) | 32 (29.6) | 59 (28.5) |
≥ 5 days, n (%) | 71 (71.7) | 72 (66.7) | 143 (69.1) |
Missing, n (%) | 1 (1.0) | 4 (3.7) | 5 (2.4) |
Mean (standard deviation), days | 9.8 (7.7) | 9.8 (13.4) | 9.8 (11.0) |
Median (range), days | 8.0 (1, 42) | 6.0 (1, 116) | 7.0 (1, 116) |
Duration of prior mechanical ventilation† | |||
< 5 days, n (%) | 88 (88.9) | 93 (86.1) | 181 (87.4) |
≥ 5 days, n (%)‡ | 11 (11.1) | 12 (11.1) | 23 (11.1) |
Missing, n (%) | 0 | 3 (2.8) | 3 (1.4) |
Mean (standard deviation), days | 2.20 (3.08) | 3.13 (8.30) | 2.68 (6.33) |
Median (range), days | 1.18 (0.02, 20.06) | 1.14 (0.04, 79.04) | 1.14 (0.04, 79.04) |
PaO2/FiO2 | |||
≤ 240 mmHg, n (%) | 75 (75.8) | 79 (73.1) | 154 (74.4) |
> 240 mmHg, n (%) | 23 (23.2) | 27 (25.0) | 50 (24.2) |
Missing, n (%) | 1 (1.0) | 2 (1.9) | 3 (1.4) |
Bacteremia (any pathogen) | |||
Yes, n (%) | 14 (14.1) | 11 (10.2) | 25 (12.1) |
No, n (%) | 85 (85.9) | 97 (89.8) | 182 (87.9) |
Number of baseline LRT pathogens | |||
None confirmed, n (%) | 24 (24.2) | 24 (22.2) | 48 (23.2) |
Monomicrobial, n (%) | 42 (42.4) | 45 (41.7) | 87 (42.0) |
Polymicrobial, n (%) | 33 (33.3) | 39 (36.1) | 72 (34.8) |