Fig. 3
From: Serum uric acid, disease severity and outcomes in COVID-19
Low serum uric acid levels associate with disease severity and outcome in COVID-19 (pooled data from discovery and validation cohorts). a Proportion of patients with hypouricemia (bar graph) and lowest serum uric acid level (scatter plots with median) according to COVID-19 severity. Circles represent individual values and black lines are medians (one-way ANOVA and linear trend, P = 0.002). b Comparison of peak values of highly sensitive C-reactive protein (hsCRP) and lactate dehydrogenase (LDH), and nadir of lymphocytes in patients with or without hypouricemia. Circles represent individual values and lines are medians. ***P < 0.001 using Mann–Whitney test. c Proportion of patients requiring mechanical ventilation, according to the presence (red dots) or not (gray dots) of hypouricemia. d Survival analyses with Kaplan–Meier curves showing time to mechanical ventilation or death (log-rank test, P < 0.001)