Table 2 Univariate and multivariate analysis of risk factors for death in children with purpura fulminans, N = 1042
Characteristics | Deaths n (%) | Univariate analysis | Multivariate analysis backward stepwise model | ||
|---|---|---|---|---|---|
OR (95% CI) | p | OR (95% CI) | p | ||
Age (years) | |||||
0–1 | 56/228 (24.6) | 3.4 [2.1; 5.4] | < 0.001 | 2.3 [1.4; 3.7] | 0.001 |
1–2 | 37/193 (19.2) | 2.5 [1.5; 4.1] | 0.001 | 2.2 [1.3; 3.7] | 0.004 |
2–4 | 28/212 (13.2) | 1.6 [0.9; 2.7] | 0.09 | 1.5 [0.9; 2.7] | 0.124 |
> 4 | 32/365 (8.8) | 1 | 1 | ||
Daycare modality | |||||
Child minder | 8/57 (14.0) | 1.3 [0.6; 3.0] | 0.5 | ||
Home | 66/352 (18.8) | 1.9 [1.2; 2.8] | 0.003 | ||
Daycare centre | 45/410 (11.0) | 1 | |||
Prematurity | |||||
No | 64/495 (12.9) | 1 | |||
Yes | 12/64 (18.8) | 1.6 [0.8; 3.1] | 0.2 | ||
Clinical profiles | |||||
PFMen + | 82/629 (13.0) | 1 | |||
PFMen- | 19/113 (16.8) | 1.3 [0.8; 2.3] | 0.3 | ||
PFLP- | 52/256 (20.3) | 1.7 [1.2; 2.5] | 0.007 | ||
Initial antibiotic therapy by 3GC | |||||
No | 0 | ||||
Yes | 166/1032 (16.1) | NA | |||
Antibiotic treatment within the 24 h before admission | |||||
No | 79/488 (16.2) | ||||
Yes | 45/407 (11.1) | 0.6 [0.4; 1.0] | 0.028 | ||
Blood culture | |||||
Positive | 63/337 (18.7) | 1.5 [1.0; 2.3] | 0.051 | ||
Negative | 42/321 (13.1) | 1 | |||
CRP level | |||||
< 100 mg/L | 32/204 (15.7) | 2.4 [1.2; 4.6] | 0.010 | ||
> 100 mg/L | 14/194 (7.2) | 1 | |||
Leukocyte count | |||||
< 5000/mm3 | 56/173 (32.4) | 2.2 [1.3; 3.7] | 0.004 | 2.1 [1.2; 3.6] | 0.006 |
5000–10,000/mm3 | 26/144 (18.1) | 1 | 1 | ||
> 10,000/mm3 | 19/407 (4.7) | 0.2 [0.1; 0.4] | < 0.001 | 0.3 [0.1; 0.5] | < 0.001 |
Neutrophil count | |||||
< 1500/mm3 | 30/66 (45.5) | 4.0 [2.2; 7.2] | < 0.001 | ||
1500–10,000/mm3 | 43/251 (17.1) | 1 | |||
> 10,000/mm3 | 5/263 (1.9) | 0.1 [0.0; 0.2] | < 0.001 | ||