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Table 2 Comparison of respiratory and hemodynamic variables of COVID-19 and non-COVID-19 acute respiratory distress syndrome

From: COVID-19 ARDS is characterized by higher extravascular lung water than non-COVID-19 ARDS: the PiCCOVID study

Variables COVID-19 (N = 60) Non-COVID-19 (N = 60) p value
Respiratory characteristics at baseline    
PaO2/FiO2 (mmHg) 129 (97–175) 138 (96–172) 0.578
TV (mL/kg PBW) 6.0 (5.7–6.1) 6.0 (5.7–6.3) 0.341
PEEP (cmH2O) 13 (10–15) 12 (10–15) 0.243
Driving pressure (cmH2O) 13 (11–15) 13 (9–17) 0.373
Crs (mL/cmH2O) 31 (25–38) 31 (24–44) 0.469
Maximal/minimal values of respiratory characteristics during TPTD monitoring    
PaO2/FiO2min (mmHg) 81 (70–109) 100 (80–124) 0.024
PEEPmax (cmH2O) 15 (12–16) 14 (12–16) 0.207
DPmax (cmH2O) 16 (15–18) 16 (12–21) 0.497
Crsmin (mL/cmH2O) 25 (21–28) 23 (16–36) 0.955
Hemodynamic variables and CRP at baseline    
CI (L/min/m2) 2.8 (2.1–3.5) 2.8 (2.5–4.2) 0.115
GEDVi (mL/m2) 728 (588–824) 696 (585–824) 0.559
EVLWi (mL/kg) 17 (14–21) 15 (11–19) 0.029
PVPI 3.5 (2.9–4.5) 2.8 (2.2–3.7) 0.005
GEF (%) 20 (15–24) 18 (15–23) 0.097
NE (µg/kg/min) 0.32 (0.13–0.63) 0.74 (0.49–1.45)  < 0.001
Lactate (mmol/L) 1.6 (1.3–2.1) 2.2 (1.2–3.5) 0.028
CRP (mg/L) 218 (146–295) 248 (125–321) 0.458
Maximal/minimal values of hemodynamic variables and CRP during TPTD monitoring    
CImin (L/min/m2) 2.4 (2.0–2.8) 2.5 (2.0–3.0) 0.524
GEDVimin (mL/m2) 634 (548–752) 600 (538–712) 0.278
EVLWimax (mL/kg) 24 (18–27) 21 (15–24) 0.005
PVPImax 4.6 (3.8–5.7) 4.1 (3.3–4.8) 0.006
GEFmin (%) 16 (13–19) 15 (11–19) 0.258
NEmax (µg/kg/min) 0.51 (0.16–0.89) 1.01 (0.52–1.74) 0.000
Lactatemax (mmol/L) 2.0 (1.6–2.7) 2.7 (2.1–4.3) 0.001
Fluid balance (mL/day) 1016 (235–1844) 1033 (436–1715) 0.989
  1. Bold font indicates statistical significance
  2. Values are expressed as median (interquartile range) or n (%)
  3. ARDS acute respiratory distress syndrome, CI cardiac index, Crs respiratory system compliance, CRP C-reactive protein, DP driving pressure, EVLWi extravascular lung water indexed for ideal body weight, GEDVi global end-diastolic volume indexed for body surface, GEF global ejection fraction, NE Norepinephrine, PaO2/FiO2 ratio of the arterial partial pressure of oxygen over inspired fraction in oxygen, PBW predicted body weight, PEEP positive end-expiratory pressure, PVPI pulmonary vascular permeability index, TPTD transpulmonary thermodilution, TV tidal volume