|
Variables
|
COVID-19 (N = 60)
|
Non-COVID-19 (N = 60)
|
p value
|
|---|
|
Respiratory characteristics at baseline
| | | |
|
PaO2/FiO2 (mmHg)
|
129 (97–175)
|
138 (96–172)
|
0.578
|
|
TV (mL/kg PBW)
|
6.0 (5.7–6.1)
|
6.0 (5.7–6.3)
|
0.341
|
|
PEEP (cmH2O)
|
13 (10–15)
|
12 (10–15)
|
0.243
|
|
Driving pressure (cmH2O)
|
13 (11–15)
|
13 (9–17)
|
0.373
|
|
Crs (mL/cmH2O)
|
31 (25–38)
|
31 (24–44)
|
0.469
|
|
Maximal/minimal values of respiratory characteristics during TPTD monitoring
| | | |
|
PaO2/FiO2min (mmHg)
|
81 (70–109)
|
100 (80–124)
|
0.024
|
|
PEEPmax (cmH2O)
|
15 (12–16)
|
14 (12–16)
|
0.207
|
|
DPmax (cmH2O)
|
16 (15–18)
|
16 (12–21)
|
0.497
|
|
Crsmin (mL/cmH2O)
|
25 (21–28)
|
23 (16–36)
|
0.955
|
|
Hemodynamic variables and CRP at baseline
| | | |
|
CI (L/min/m2)
|
2.8 (2.1–3.5)
|
2.8 (2.5–4.2)
|
0.115
|
|
GEDVi (mL/m2)
|
728 (588–824)
|
696 (585–824)
|
0.559
|
|
EVLWi (mL/kg)
|
17 (14–21)
|
15 (11–19)
|
0.029
|
|
PVPI
|
3.5 (2.9–4.5)
|
2.8 (2.2–3.7)
|
0.005
|
|
GEF (%)
|
20 (15–24)
|
18 (15–23)
|
0.097
|
|
NE (µg/kg/min)
|
0.32 (0.13–0.63)
|
0.74 (0.49–1.45)
|
< 0.001
|
|
Lactate (mmol/L)
|
1.6 (1.3–2.1)
|
2.2 (1.2–3.5)
|
0.028
|
|
CRP (mg/L)
|
218 (146–295)
|
248 (125–321)
|
0.458
|
|
Maximal/minimal values of hemodynamic variables and CRP during TPTD monitoring
| | | |
|
CImin (L/min/m2)
|
2.4 (2.0–2.8)
|
2.5 (2.0–3.0)
|
0.524
|
|
GEDVimin (mL/m2)
|
634 (548–752)
|
600 (538–712)
|
0.278
|
|
EVLWimax (mL/kg)
|
24 (18–27)
|
21 (15–24)
|
0.005
|
|
PVPImax
|
4.6 (3.8–5.7)
|
4.1 (3.3–4.8)
|
0.006
|
|
GEFmin (%)
|
16 (13–19)
|
15 (11–19)
|
0.258
|
|
NEmax (µg/kg/min)
|
0.51 (0.16–0.89)
|
1.01 (0.52–1.74)
|
0.000
|
|
Lactatemax (mmol/L)
|
2.0 (1.6–2.7)
|
2.7 (2.1–4.3)
|
0.001
|
|
Fluid balance (mL/day)
|
1016 (235–1844)
|
1033 (436–1715)
|
0.989
|
- Bold font indicates statistical significance
- Values are expressed as median (interquartile range) or n (%)
- ARDS acute respiratory distress syndrome, CI cardiac index, Crs respiratory system compliance, CRP C-reactive protein, DP driving pressure, EVLWi extravascular lung water indexed for ideal body weight, GEDVi global end-diastolic volume indexed for body surface, GEF global ejection fraction, NE Norepinephrine, PaO2/FiO2 ratio of the arterial partial pressure of oxygen over inspired fraction in oxygen, PBW predicted body weight, PEEP positive end-expiratory pressure, PVPI pulmonary vascular permeability index, TPTD transpulmonary thermodilution, TV tidal volume
