Table 3 Clinical courses of depressive symptoms, symptoms of posttraumatic stress disorder (PTSD) and chronic pain allocated to trajectory classes

Depression

MDI 1 month after ICU discharge, median (IQR)

14.0 (10.0)

23.0 (15.0)

29.0 (7.0)

17.0 (15.0)

 < 0.001^a

 < 0.001^a

 < 0.025^a

MDI 6 months after ICU discharge, median (IQR)

7.0 (8.0)

21.0 (19.0)

11.0 (9.0)

8.0 (10.0)

 < 0.001^a

 < 0.001^a

 < 0.001^a

MDI 12 months after ICU discharge, median (IQR)

6.0 (8.0)

26.0 (12.0)

6.8 (10.0)

7.0 (10.0)

 < 0.001^a

0.172^a

 < .001^a

Chronic pain (GCPS)

Pain intensity 1 month after ICU discharge, median (IQR)

43.3 (36.7)

60.0 (23.3)

53.3 (7)

46.7 (33.3)

33 (14.7)

 < 0.001^a

 < .010^a

0.199^a

Pain intensity 6 months after ICU discharge, median (IQR)

33.3 (36.7)

53.3 (28.3)

40.0 (30.0)

36.7 (33.3)

33 (14.7)

 < 0.001^a

0.229^a

 < 0.007^a

Pain intensity 12 months after ICU discharge, median (IQR)

30.0 (38.3)

41.7 (38.3)

40.0 (40.0)

33.3 (36.7)

33 (14.7)

 < 0.009^a

 < .038^a

0.413^a

Disability from pain 1 month after ICU discharge, median (IQR)

23.3 (50.0)

56.7 (60.0)

50.0 (66.7)

33.3 (63.3)

33 (14.7)

 < 0.001^a

 < 0.001^a

0.548^a

Disability from pain 6 months after ICU discharge, median (IQR)

20.0 (40.0)

56.7 (70.0)

30.0 (50.0)

26.7 (50.0)

33 (14.7)

 < 0.001^a

0.230^a

 < 0.005^a

Disability from pain 12 months after ICU discharge, median (IQR)

13.3 (36.7)

40.0 (50.0)

20.0 (50.0)

20.0 (46.7)

33 (14.7)

 < 0.001^a

0.130^a

 < 0.042^a

Posttraumatic stress

PTSS-10 score 1 month after ICU discharge, median (IQR)

17.0 (10.0)

34.5 (9.0)

30.5 (15.0)

22.0 (15.0)

1 (0.4)

 < 0.001^b

 < 0.001^b

0.367^b

PTSS-10 score 6 months after ICU discharge, median (IQR)

17.0 (9.0)

40.0 (16.0)

23.5 (16.0)

19.0 (13.0)

18 (8.0)

 < 0.001^b

 < 0.001^b

 < 0.001^b

PTSS-10 score 12 months after ICU discharge, median (IQR)

17.0 (10.0)

41.0 (19.0)

20.0 (13.0)

20.0 (14.0)

22 (9.8)

 < 0.001^b

0.069^b

 < 0.001^b

PTSS-10 score > 34

1 month after ICU discharge, no. (%)

7.0 (4.6)

13.0 (48.1)

15.0 (33.3)

35.0 (15.7)

1 (0.4)

 < 0.001^c

 < 0.001^c

0.212^c

PTSS-10 score > 34

6 months after ICU discharge, no. (%)

6.0 (4.3)

14.0 (53.8)

7.0 (17.1)

27.0 (13.1)

18 (8.0)

 < 0.001^c

 < 0.006^c

 < 0.002^c

PTSS-10 score > 34

12 months after ICU discharge, no. (%)

8.0 (5.8)

15.0 (62.5)

5.0 (12.2)

28.0 (13.9)

22 (9.8)

 < 0.001^c

0.170^c

 < 0.001^c