Adverse events associated with administration of vasopressor medications through a peripheral intravenous catheter: a systematic review and meta-analysis

Owen, Victoria S.; Rosgen, Brianna K.; Cherak, Stephana J.; Ferland, Andre; Stelfox, Henry T.; Fiest, Kirsten M.; Niven, Daniel J.

doi:10.1186/s13054-021-03553-1

Critical Care

Table 1 Characteristics of included studies

From: Adverse events associated with administration of vasopressor medications through a peripheral intravenous catheter: a systematic review and meta-analysis

Author (year)	Study location	Location of care	Study design	Patients (n)	Received PIV vasopressors (n)	Adverse events associated with PIV vasopressors^a (n)	Included in meta-analysis
Studies in adults
Andrews [35]	Zambia	ED	RCT^b	209	17^c	0	Yes
Johnson, W. [30]	USA^d	Surgical ICU	RCT^e	25	11	1	Yes
Medlej [10]	Lebanon^d	ED/ICU	Prospective cohort	55	55	3	Yes
Lewis [3]	USA	Medical ICU/ step down unit	Retrospective cohort	202	202^f	8	Yes
Pancaro [11]	Netherlands	OR	Retrospective cohort	14,385	14,385	5	Yes
Datar [9]	USA	Neuro ICU	Retrospective cohort	277	277	9	Yes
Hallengren [36]	Sweden	Intermediate care unit	Retrospective cohort	91	79	0	Yes
Delgado [34] ^g	USA	Neuro ICU	Retrospective cohort	20	20	1	Yes
Cardenas-Garcia [2]	USA	Medical ICU	Combined prospective /retrospective cohort	734	734^h	19	Yes
Putland [31]	Australia	ED	Retrospective cohort	220	220	7ⁱ	Yes
Rojewski-Rojas [37]^j,k	Spain	ED	Retrospective cohort	55	55	2	Yes
Delaney [29]	Multinational^l	ED	Post-hoc analysis of RCT^m	937	389	–ⁿ	No^o
White [28]	USA	Hospital^p	Prospective cohort	188	13^q	1	No^q
Dugger [27]^k	USA	Hospital^p	Combined prospective /retrospective cohort	25^r	25^r	17^r	No ^q
Zucker [24]^k	USA	Hospital^p	Cohort study^s	68	68	22^t	No^u
Moyer [23]	USA	Hospital^p	Cohort study^s	20	20	–^o	No^o
Studies in children
Kumar [12]	India	Pediatric ICU/ED	Prospective cohort	204	190	3	Yes
Patregnani [13]	USA	Pediatric ICU	Retrospective cohort	102	102	2	Yes
Turner [32]	USA	Transport to Pediatric ICU	Retrospective cohort	73	73	11	Yes
Lampin [33]	France	Pediatric ICU	Retrospective cohort	144	23^v	0^v	Yes^v
Ventura [14]	Brazil	ED/Pediatric ICU	RCT^w	120	–^w	0	No^r
Stanley [26]	USA	Neonatal ICU	RCT^x	772^s	–^q	–^o	No^o,q
Johnson [25]	USA	Neonatal ICU	Prospective cohort	69	– ^q	1	No ^q

^aLocal anatomic adverse events as defined by each individual study
^bRCT examining outcomes between septic patients admitted to the ED
^cAdverse events were only monitored for within the first 6 h of admission to ED
^dImplied
^eRCT examining routes of vasopressin administration (peripheral and superior mesenteric artery)
^f340 PIVs administering vasopressors in 202 patients
^gPilot study with an age range of 14–90 years
^h783 infusions in 734 patients. 49 patients had more than one PIV infusions
ⁱStudy had 11 cases of local tissue ischemia happened in 7 patients (5 in same patient)
^jStudy abstract with poster only. Data preferentially taken from poster
^kImplied adult population
^lMost of the 51 centers included in original RCT were in Australia or New Zealand
^mUsed data from ARISE trial [45]
ⁿAdverse events related to administration of vasopressors through a PIV not recorded in original RCT
^oDoes not clearly report the numbers of adverse events
^pUnclear specific location of care within the hospital
^qDoes not clearly report the number of patients that received vasopressors through a PIV
^rNumber of infusions, could be more infusions than patients
^sUnclear if data was collected prospectively or retrospectively
^tStudy had 34 extravasations happened in 22 patients
^uReports adverse events with non-standard PIV insertion technique (cut downs to cannulate veins)
^vStudy reports 1 case of PIV dopamine extravasation causing ischemia and skin necrosis, but as it does not report total number of PIV dopamine. Numbers included in meta-analysis are only for epinephrine
^wPatients were randomly assigned to either received dopamine or epinephrine through a PIV or IO in fluid-refractory septic shock. No stratification was done between PIV and IO administration
^xPatients randomized between vialon and Teflon catheters

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ISSN: 1364-8535

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