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Table 2 Physiologic variables before, during and after prone positioning (n = 78)

From: Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients

Variables Baseline Prone Supine p value
PEEP (cmH2O) 14 (12–15) 14 (12–15) 14 (12–15) 0.679
FiO2 (%) 70 (60–90) 60 (50–70)a 60 (45–80)a  < 0.001
Tidal volume/PBW (mL/kg) 6.8 (6.1–7.6) 6.7 (6.2–7.3) 6.8 (6.2–7.4) 0.619
Driving pressure (cmH2O) 11 (10–14) 11 (10–14) 11 (9–14) 0.147
Plateau pressure (cmH2O) 25 (22–28) 24 (23–27) 24 (23–28) 0.324
Respiratory rate (breaths/min) 20 (18–22) 22 (20–24)a 22 (20–24)a  < 0.001
Minute ventilation (L/min) 9.4 (7.7–11.0) 9.6 (8.3–11.2) 9.9 (8.2–11.2) 0.052
Corrected minute ventilation (L/min) 12.6 (9.8–15.2) 12.6 (9.5–15.7) 12.2 (10.3–14.9) 0.881
PaCO2 (mmHg) 53 (45–60) 53 (43–59) 52 (46–60) 0.302
Respiratory system Compliance (mL/cmH2O) 43 (31–50) 42 (35–48) 41 (34–48) 0.943
PaO2/FiO2 ratio 98 (72–121) 158 (112–220)a 128 (87–174)a,b  < 0.001
Ventilatory ratio 2.0 (1.6–2.4) 2.0 (1.5–2.5) 1.9 (1.6–2.5) 0.881
  1. Data are expressed as median (interquartile range)
  2. PEEP = Positive End-Expiratory Pressure; FiO2 = fraction of inspired oxygen; PBW = Predicted Body Weight; PaCO2 = partial pressure of carbon dioxide in arterial blood
  3. ap < 0.05 versus baseline
  4. bp < 0.05 versus prone