Fig. 2

Plasma levels of a C-reactive protein, b procalcitonin, c white blood cell counts, d ferritin, and e body temperature on day of admission to the intensive care unit (ICU), start of anakinra therapy, and until 8 days following cessation of anakinra. Results of 13 anakinra-treated patients of which data were available on multiple days after cessation of anakinra treatment are shown. Data are presented as geometric mean with 95% confidence intervals. Anakinra therapy was initiated 12 [7–17] and ceased 22 [18–25] days following ICU admission (median [IQR]). P-values were calculated using paired t-tests and mixed effect model analysis on log-transformed data. No inflammatory rebound effect was observed following cessation of anakinra therapy