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Fig. 4 | Critical Care

Fig. 4

From: Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study

Fig. 4

Longitudinal plasma biomarker concentrations in ICU patients with and without COVID-19 demonstrates divergent Ang-2, sTNFR-1 and sRAGE concentrations. Ang-2 and sTNFR-1 concentrations are decreasing in non-COVID-19 and increasing in COVID-19 from days 1 to 3 (p < 0.001 and p = 0.005, respectively). In contrast, sRAGE concentrations are increasing in non-COVID-19 and decreasing in COVID-19 from days 1 to 3 (p = 0.003). The trend of biomarker concentrations is provided from days 1 to 3 of ICU admission. P-value tests whether the ratio of the fold-change from day 1 to day 3 differs between patients with and without COVID-19 (among the subset of patients with day 1 and day 3 biomarkers). Longitudinal plasma biomarker concentrations are analyzed in the patients with days 1 and 3 biomarker measurements (non-COVID-19, n = 34 and COVID-19, n = 32)

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Critical Care

ISSN: 1364-8535