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Table 4 SYN-1, S1P and VE-cadherin concentrations over time in 375 patients and by ALBIOS treatment

From: Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS

  ALBIOS patients p value*
Total
(375)
Albumin
(188)
Crystalloids
(187)
SYN-1
(ng/mL)
   
 Day 1 185 [90–381] 176 [86–381] 184 [94–385] 0.41
 Day 2 420 [239–962] 400 [228–954] 422 [247–984] 0.29
 Day 7 481 [264–960] 469 [255–904] 502 [289–1000] 0.37
Mixed model analysis**   P time 7.6 × 10–80
P treatment 0.253
P interaction time*treatment 0.883
S1P
(ng/mL)
    
 Day 1 86.5 [63.7–120.0] 87.6 [62.8–123.7] 84.2 [64.0–118.8] 0.91
 Day 2 87.2 [67.6–122.1] 90.0 [66.9–128.5] 86.2 [67.7–117.2] 0.35
 Day 7 91.6 [69.9–132.9] 93.0 [70.6–138.9] 89.9 [68.0–127.9] 0.29
Mixed model analysis**   P time 0.001
P treatment 0.147
P interaction time*treatment 0.717
VE-cadherin
(ng/mL)
    
 Day 1 1697 [1313–2199] 1636 [1270–2068] 1737 [1394–2317] 0.004
 Day 2 1751 [1433–2310] 1662 [1381–2144] 1837 [1475–2398] 0.009
 Day 7 1869 [1523–2332] 1781 [1494–2251] 1976 [1618–2395] 0.02
Mixed model analysis**   P time 4.5 × 10–13
P treatment 0.003
P interaction time*treatment 0.193
  1. All biomarker concentrations are reported as median [IQR]
  2. SYN-1, syndecan-1; S1P, sphingosine 1-phosphate; IQR, interquartile range;
  3. *p value for Mann–Whitney to compare ALBIOS-Albumin vs ALBIOS-crystalloids
  4. **p value for mixed model analysis including biomarker value at three time points and treatment. A Greenhouse–Geisser correction was included to correct for sphericity