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Table 2 Summary of clinical publications reviewed

From: Systematic review of cognitive impairment and brain insult after mechanical ventilation

Publication

Study type

Number of patients

Summary of participants

Outcomes analyzed

Delirium

Long-term cognitive impairment

2002, Granberg et al. [19]

Prospective cohort study

19

Mechanically ventilated ICU patients

Yes

–

2004, Ely et al. [20]

Prospective cohort study

275

Mechanically ventilated ICU patients

Yes

Yes

2006, Peterson et al. [21]

Prospective cohort study

375

ICU patients

Yes

–

2007, Balas et al. [22]

Prospective cohort study

114

ICU patients

Yes

–

2008, Lin et al. [23]

Prospective cohort study

143

Mechanically ventilated ICU patients

Yes

–

2009, Rompaey et al. [24]

Prospective cohort study

523

ICU patients

Yes

–

2010, Girard et al. [25]

Prospective cohort study

126

Mechanically ventilated ICU patients

Yes

Yes

2010, Tsuruta et al. [26]

Prospective cohort study

172

ICU patients

Yes

–

2010, Shehabi et al. [27]

Prospective cohort study

354

Mechanically ventilated ICU patients

Yes

–

2012, Sharma et al. [28]

Prospective cohort study

140

ICU patients

Yes

–

2013, Haas et al. [29]

Prospective cohort study

1216

ICU patients

Yes

Yes

2013, Norkiene et al. [30]

Prospective cohort study

87

Cardiovascular surgery patients

Yes

–

2014, Brummel et al. [31]

Prospective cohort study

126

Mechanically ventilated ICU patients

Yes

Yes

2014, Tsuruta et al. [32]

Prospective cohort study

180

Mechanically ventilated ICU patients

Yes

Yes

2014, Connor et al. [33]

Prospective cohort study

80

Mechanically ventilated ICU patients

Yes

–

2015, Mehta et al. [34]

Prospective cohort study

430

Mechanically ventilated ICU patients

Yes

Yes

2015, Hsieh et al. [35]

Prospective cohort study

564

Mechanically ventilated ICU patients

Yes

–

2016, Almeida et al. [36]

Prospective cohort study

113

ICU patients

Yes

–

2017, Chen et al. [37]

Prospective cohort study

620

ICU patients

Yes

–

2017, Mesa et al. [38]

Prospective cohort study

230

Mechanically ventilated ICU patients

Yes

–

2017, Rueden et al. [39]

Prospective cohort study

215

Trauma patients

Yes

–

2018, Shehabi et al. [40]

Prospective cohort multicenter study

710

Mechanically ventilated ICU patients

Yes

–

2018, Singh et al. [41]

Retrospective cohort study

67,333

ICU patients

Yes

–

2018, Sanchez-Hurtado et al. [42]

Prospective cohort study

109

ICU/cancer patients

Yes

–

2018, Mitchell et al. [43]

Prospective cohort study

148

Mechanically ventilated ICU patients

Yes

Yes

2019, Torres-Contreras et al. [44]

Prospective cohort study

134

ICU patients

Yes

–