Fig. 9

Multistate modelling and Cox regression analysis outcomes for patient with static compliance recorded within 48 h of commencing mechanical ventilation. a Multistate model structure for estimating expected outcomes up to 28 days from admission to intensive care unit (ICU). Modelled health states include not on invasive mechanical ventilation (non-MV), on mechanical ventilation (MV), ICU discharge and death. Patients start in the non-MV state if not mechanically ventilated upon or prior to ICU admission, or in the MV state otherwise. b Predicted probabilities of occupying health states up to 28 days from ICU admission. c Results of Cox proportional hazards modelling for risk of death and ICU discharge from commencement of mechanical ventilation. Covariates comprise age, body mass index (BMI), selected comorbidities (hypertension, chronic cardiac disease, chronic kidney disease) and baseline static compliance. Parameter estimates are presented as estimated hazard ratios with 95% confidence intervals (CI). Further details on factors significantly associated with assessed outcomes are available in the results section