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Table 2 Haemodynamic variables at different study steps

From: Do changes in pulse pressure variation and inferior vena cava distensibility during passive leg raising and tidal volume challenge detect preload responsiveness in case of low tidal volume ventilation?

  

Baseline 1

(Vt = 6 mL/kg)

PLR

(Vt = 6 mL/kg)

P

PLR versus baseline 1

Baseline 2

(Vt = 6 mL/kg)

Vt challenge

(Vt = 8 mL/kg)

P

Vt challenge versus baseline 2

Baseline 3

(Vt = 6 mL/kg)

After VE

(Vt = 6 mL/kg)

P

After VE versus baseline 3

HR (beats/min)

Preload responders

85 ± 18

77 ± 11

0.10

85 ± 17

88 ± 19

0.65

84 ± 17

90 ± 15

0.37

Preload non-responders

74 ± 18

74 ± 19

1.95

74 ± 18

75 ± 22

0.89

   

SAP (mmHg)

Preload responders

118 ± 17

124 ± 21

0.40

119 ± 17

116 ± 19

0.65

120 ± 17

129 ± 13

0.11

Preload non-responders

128 ± 16

126 ± 19

0.76

128 ± 16

130 ± 16

0.73

   

MAP (mmHg)

Preload responders

75 ± 12

79 ± 14

0.41

76 ± 12

75 ± 14

0.85

79 ± 13

83 ± 10

0.35

Preload non-responders

87 ± 12

86 ± 12

0.82

87 ± 12

85 ± 8

0.59

   

DAP (mmHg)

Preload responders

57 ± 10

59 ± 12

0.62

57 ± 11

59 ± 15

0.68

56 ± 11

58 ± 9

0.59

Preload non-responders

61 ± 10

60 ± 8

0.76

62 ± 9

69 ± 10

0.06

   

CVP (mmHg)

Preload responders

10 ± 3

11 ± 3

< 0.01

9 ± 5

10 ± 5

< 0.01

11 ± 3

12 ± 6

< 0.01

Preload non-responders

10 ± 2

12 ± 3

< 0.01

12 ± 4

11 ± 4

< 0.01

   

IAP (mmHg)

Preload responders

8 ± 3

7 ± 4

0.04

8 ± 3

8 ± 3

1.00

6 ± 2

6 ± 2

1.00

Preload non-responders

7 ± 4

6 ± 3

0.06

7 ± 3

7 ± 3

0.98

   

CI (L/min/m2)

Preload responders

3.0 ± 0.9

3.5 ± 1.3

< 0.01

3.0 ± 1.3

2.7 ± 1.1

< 0.01

2.8 ± 0.9

3.4 ± 1.2

< 0.01

Preload non-responders

3.0 ± 1.1

3.0 ± 0.9

0.78

3.0 ± 0.9

3.0 ± 0.8

0.39

   

Pplat (cmH2O)

Preload responders

22.2 ± 6.2

22.2 ± 6.2

1.00

22.2 ± 6.2

24.5 ± 5.4

0.01

22.3 ± 6.1

22.3 ± 6.1

1.00

Preload non-responders

22.9 ± 4.6

22.9 ± 4.6

1.00

22.9 ± 4.6

24.8 ± 5.2

0.01

   

PEEP (cmH2O)

Preload responders

10.7 ± 3.6

10.7 ± 3.6

1.00

10.7 ± 3.6

10.7 ± 3.6

1.00

10.7 ± 3.6

10.7 ± 3.6

1.00

Preload non-responders

10.4 ± 3.0

10.4 ± 3.0

1.00

10.4 ± 3.0

10.4 ± 3.0

1.00

   

Driving pressure (cmH2O)

Preload responders

11.5 ± 2.2

11.7 ± 2.3

0.90

11.5 ± 2.2

13.8 ± 1.9

0.03

11.5 ± 2.2

11.5 ± 2.2

1.00

Preload non-responders

12.3 ± 2.2

12.4 ± 2.2

0.95

12.3 ± 2.2

14.4 ± 2.4

0.01

   

PPV (%)

Preload responders

8 ± 3

5 ± 2

< 0.01

8 ± 3

13 ± 4

< 0.01

8 ± 2

4 ± 2

< 0.01

Preload non-responders

6 ± 3

6 ± 3

0.08

7 ± 3

6 ± 3

0.84

   

SVV (%)

Preload responders

8 ± 2

6 ± 2

< 0.01

8 ± 2

12 ± 3

< 0.01

8 ± 2

5 ± 2

< 0.01

Preload non-responders

6 ± 3

6 ± 3

0.43

6 ± 3

5 ± 2

0.31

   

IVCDV (%)

Preload responders

9 ± 3

7 ± 2

0.01

10 ± 2

15 ± 3

< 0.01

8 ± 2

6 ± 3

0.04

Preload non-responders

7 ± 3

6 ± 2

0.22

7 ± 3

6 ± 3

0.17

   

IVC max diam (cm)

Preload responders

2.0 ± 0.2

2.1 ± 0.2

< 0.01

1.9 ± 0.2

2.1 ± 0.2

0.26

1.9 ± 0.2

2.1 ± 0.3

< 0.01

Preload non-responders

2.0 ± 0.4

2.1 ± 0.4

0.02

2.3 ± 0.3

2.3 ± 0.3

0.84

   

VTI (cm)

Preload responders

20 ± 4

24 ± 6

0.01

21 ± 5

18 ± 6

0.04

20 ± 4

25 ± 5

< 0.01

Preload non-responders

21 ± 4

21 ± 4

0.89

21 ± 4

21 ± 4

0.89

   

EVLW (mL/Kg)

Preload responders

14 ± 7

  

14 ± 7

  

14 ± 6

13 ± 5

0.62

Preload non-responders

13 ± 4

  

13 ± 4

     

PVPI

Preload responders

2.6 ± 1.0

  

2.7 ± 1.0

  

2.7 ± 1.2

2.6 ± 1.0

0.81

Preload non-responders

2.5 ± 1.0

  

2.6 ± 1.0

     

GEDV (mL/m2)

Preload responders

725 ± 142

  

645 ± 100

  

695 ± 124

794 ± 135

0.04

Preload non-responders

821 ± 125

  

820 ± 178

     

CFI (−1)

Preload responders

4.1 ± 1.5

  

4.2 ± 1.7

  

4.2 ± 1.6

4.2 ± 1.6

0.85

Preload non-responders

4.5 ± 2.1

  

4.2 ± 1.6

     
  1. P values in bold: < 0.05
  2. CI cardiac index, CFI cardiac function index, CVP central venous pressure, DAP diastolic arterial pressure, EVLW extravascular vascular lung water indexed for body weight, GEDV global end-diastolic volume indexed for body surface, HR heart rate, IAP intra-abdominal pressure, IVC inferior vena cava, IVCDV: inferior vena cava variation, MAP mean arterial pressure, PEEP positive end-expiratory pressure, PLR passive leg raising, Pplat plateau pressure, PPV pulse pressure variation, PVPI pulmonary vascular permeability index, SAP systolic arterial pressure, SVV stroke volume variation, VE volume expansion, Vt tidal volume, VTI velocity time integral
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Critical Care

ISSN: 1364-8535