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Table 2 Haemodynamic variables at different study steps

From: Do changes in pulse pressure variation and inferior vena cava distensibility during passive leg raising and tidal volume challenge detect preload responsiveness in case of low tidal volume ventilation?

   Baseline 1
(Vt = 6 mL/kg)
PLR
(Vt = 6 mL/kg)
P
PLR versus baseline 1
Baseline 2
(Vt = 6 mL/kg)
Vt challenge
(Vt = 8 mL/kg)
P
Vt challenge versus baseline 2
Baseline 3
(Vt = 6 mL/kg)
After VE
(Vt = 6 mL/kg)
P
After VE versus baseline 3
HR (beats/min)
Preload responders 85 ± 18 77 ± 11 0.10 85 ± 17 88 ± 19 0.65 84 ± 17 90 ± 15 0.37
Preload non-responders 74 ± 18 74 ± 19 1.95 74 ± 18 75 ± 22 0.89    
SAP (mmHg)
Preload responders 118 ± 17 124 ± 21 0.40 119 ± 17 116 ± 19 0.65 120 ± 17 129 ± 13 0.11
Preload non-responders 128 ± 16 126 ± 19 0.76 128 ± 16 130 ± 16 0.73    
MAP (mmHg)
Preload responders 75 ± 12 79 ± 14 0.41 76 ± 12 75 ± 14 0.85 79 ± 13 83 ± 10 0.35
Preload non-responders 87 ± 12 86 ± 12 0.82 87 ± 12 85 ± 8 0.59    
DAP (mmHg)
Preload responders 57 ± 10 59 ± 12 0.62 57 ± 11 59 ± 15 0.68 56 ± 11 58 ± 9 0.59
Preload non-responders 61 ± 10 60 ± 8 0.76 62 ± 9 69 ± 10 0.06    
CVP (mmHg)
Preload responders 10 ± 3 11 ± 3 < 0.01 9 ± 5 10 ± 5 < 0.01 11 ± 3 12 ± 6 < 0.01
Preload non-responders 10 ± 2 12 ± 3 < 0.01 12 ± 4 11 ± 4 < 0.01    
IAP (mmHg)
Preload responders 8 ± 3 7 ± 4 0.04 8 ± 3 8 ± 3 1.00 6 ± 2 6 ± 2 1.00
Preload non-responders 7 ± 4 6 ± 3 0.06 7 ± 3 7 ± 3 0.98    
CI (L/min/m2)
Preload responders 3.0 ± 0.9 3.5 ± 1.3 < 0.01 3.0 ± 1.3 2.7 ± 1.1 < 0.01 2.8 ± 0.9 3.4 ± 1.2 < 0.01
Preload non-responders 3.0 ± 1.1 3.0 ± 0.9 0.78 3.0 ± 0.9 3.0 ± 0.8 0.39    
Pplat (cmH2O)
Preload responders 22.2 ± 6.2 22.2 ± 6.2 1.00 22.2 ± 6.2 24.5 ± 5.4 0.01 22.3 ± 6.1 22.3 ± 6.1 1.00
Preload non-responders 22.9 ± 4.6 22.9 ± 4.6 1.00 22.9 ± 4.6 24.8 ± 5.2 0.01    
PEEP (cmH2O)
Preload responders 10.7 ± 3.6 10.7 ± 3.6 1.00 10.7 ± 3.6 10.7 ± 3.6 1.00 10.7 ± 3.6 10.7 ± 3.6 1.00
Preload non-responders 10.4 ± 3.0 10.4 ± 3.0 1.00 10.4 ± 3.0 10.4 ± 3.0 1.00    
Driving pressure (cmH2O)
Preload responders 11.5 ± 2.2 11.7 ± 2.3 0.90 11.5 ± 2.2 13.8 ± 1.9 0.03 11.5 ± 2.2 11.5 ± 2.2 1.00
Preload non-responders 12.3 ± 2.2 12.4 ± 2.2 0.95 12.3 ± 2.2 14.4 ± 2.4 0.01    
PPV (%)
Preload responders 8 ± 3 5 ± 2 < 0.01 8 ± 3 13 ± 4 < 0.01 8 ± 2 4 ± 2 < 0.01
Preload non-responders 6 ± 3 6 ± 3 0.08 7 ± 3 6 ± 3 0.84    
SVV (%)
Preload responders 8 ± 2 6 ± 2 < 0.01 8 ± 2 12 ± 3 < 0.01 8 ± 2 5 ± 2 < 0.01
Preload non-responders 6 ± 3 6 ± 3 0.43 6 ± 3 5 ± 2 0.31    
IVCDV (%)
Preload responders 9 ± 3 7 ± 2 0.01 10 ± 2 15 ± 3 < 0.01 8 ± 2 6 ± 3 0.04
Preload non-responders 7 ± 3 6 ± 2 0.22 7 ± 3 6 ± 3 0.17    
IVC max diam (cm)
Preload responders 2.0 ± 0.2 2.1 ± 0.2 < 0.01 1.9 ± 0.2 2.1 ± 0.2 0.26 1.9 ± 0.2 2.1 ± 0.3 < 0.01
Preload non-responders 2.0 ± 0.4 2.1 ± 0.4 0.02 2.3 ± 0.3 2.3 ± 0.3 0.84    
VTI (cm)
Preload responders 20 ± 4 24 ± 6 0.01 21 ± 5 18 ± 6 0.04 20 ± 4 25 ± 5 < 0.01
Preload non-responders 21 ± 4 21 ± 4 0.89 21 ± 4 21 ± 4 0.89    
EVLW (mL/Kg)
Preload responders 14 ± 7    14 ± 7    14 ± 6 13 ± 5 0.62
Preload non-responders 13 ± 4    13 ± 4      
PVPI
Preload responders 2.6 ± 1.0    2.7 ± 1.0    2.7 ± 1.2 2.6 ± 1.0 0.81
Preload non-responders 2.5 ± 1.0    2.6 ± 1.0      
GEDV (mL/m2)
Preload responders 725 ± 142    645 ± 100    695 ± 124 794 ± 135 0.04
Preload non-responders 821 ± 125    820 ± 178      
CFI (−1)
Preload responders 4.1 ± 1.5    4.2 ± 1.7    4.2 ± 1.6 4.2 ± 1.6 0.85
Preload non-responders 4.5 ± 2.1    4.2 ± 1.6      
  1. P values in bold: < 0.05
  2. CI cardiac index, CFI cardiac function index, CVP central venous pressure, DAP diastolic arterial pressure, EVLW extravascular vascular lung water indexed for body weight, GEDV global end-diastolic volume indexed for body surface, HR heart rate, IAP intra-abdominal pressure, IVC inferior vena cava, IVCDV: inferior vena cava variation, MAP mean arterial pressure, PEEP positive end-expiratory pressure, PLR passive leg raising, Pplat plateau pressure, PPV pulse pressure variation, PVPI pulmonary vascular permeability index, SAP systolic arterial pressure, SVV stroke volume variation, VE volume expansion, Vt tidal volume, VTI velocity time integral