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Table 3 Predictors of deterioration of frailty status* from baseline to 6 months of follow-up

From: Frailty status among older critically ill patients with severe acute kidney injury

Variables

Univariable

Multivariable

OR (CI)

p-value

OR (CI)

p-value

Age

1.04 (1.001–1.09)

0.048

1.08 (1.03–1.13)

0.003

Charlson comorbidity index

0.93 (0.80–1.07)

0.316

0.91 (0.77–1.08)

0.279

APACHE II score

1.01 (0.97–1.05)

0.609

1.01 (0.97–1.06)

0.643

Pre-hospital disposition

Home without assistance

Reference category

Reference category

Home with assistance

0.53 (0.22–1.33)

0.176

0.94 (0.29–3.01)

0.910

Baseline CFS score

0.78 (0.62–0.99)

0.036

0.70 (0.52–0.94)

0.019

Hospital length of stay

1.01 (0.996–1.10)

0.274

1.01 (0.99–1.02)

0.406

ICU length of stay

0.99 (0.97–1.10)

0.419

0.99 (0.97–1.01)

0.499

Receipt of RRT

0.99 (0.54–1.80)

0.971

0.93 (0.46–1.90)

0.839

  1. *Deterioration of frailty status were defined as any forward transitions from the following categories: Fit (Clinical frailty score (CFS): 1–3), Vulnerable (CFS: 4), Mild Frailty (CFS: 5–6) and Moderate-to-Severe Frailty (CFS: 7–8).
  2. APACHE II: acute physiology and chronic health evaluation II, CFS: clinical frailty scale, CI: confidence interval, ICU: intensive care unit, OR: odds ratio, RRT: renal replacement therapy