Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood–brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observational study

Table 2 Complement proteins exhibited highest correlations with Q_A

Protein, antibody	Specific function	Protein size [kDa]	τ	adjusted p value
C1QB HPA052116	Innate immunity/complement system	26.7	0.67	< 0.001
CFB HPA001817	Innate immunity/complement system	85.5	0.66	< 0.001
C9 HPA029577	Innate immunity/complement system	63.2	0.65	< 0.001
C9 HPA070709	Innate immunity/complement system	63.2	0.65	< 0.001
C1QA HPA002350	Innate immunity/complement system	26	0.64	< 0.001
MASP2 HPA029314	Innate immunity/complement system	75.7	0.58	< 0.001
VCAM1 HPA069867	Cell cell communication	81.3	0.54	< 0.001
FCN3 HPA071173	Innate immunity/complement system	31.7–32.9^a	0.54	< 0.001
MASP2 HPA029313	Innate immunity/complement system	75.7	0.52	< 0.001
C5 HPA075945	Innate immunity/complement system	188.3	0.52	< 0.001

Top 10 Q_A correlated proteins as deemed by correlation coefficient Kendall τ. Correlations were calculated between protein CSF/serum ratio and Q_A. Protein sizes were derived from the Human Protein Atlas for the specific protein splice variant represented by the Human Protein Atlas antibody
CNS central nervous system, CSF cerebrospinal fluid, Da Dalton, Q_A albumin quotient. Full protein names are detailed in Additional file 3: Table S1
^aProtein size interval provided as Human Protein Atlas antibody is not specified for protein splice variant

ISSN: 1364-8535