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Table 3 Synthesis of results: surfactant therapies in neonates

From: Surfactant therapies for pediatric and neonatal ARDS: ESPNIC expert consensus opinion for future research steps

  1. Boxes were colored in green or red if, for a given outcome, the surfactant treatment had a positive effect or none, respectively. Boxes were left blank where no data were available
  2. #This study enrolled a mixed population of NARDS induced by meconium aspiration or sepsis but also non-ARDS conditions such as RDS or idiopathic persistent pulmonary hypertension of the neonate
  3. †Same results with other oxygenation metrics; results obtained with up to 3 surfactant doses
  4. *Trend which does not reach significance threshold. #There was a significant reduction in the composite outcome mortality/need for extracorporeal life support. Raw mortality was not different between the two arms
  5. @In addition to these outcomes, there was a trend for a clinically less severe respiratory distress
  6. ECMO extra-corporeal membrane oxygenation, PPHN persistent pulmonary hypertension of the neonate, RDS neonatal respiratory distress syndrome (hyaline membrane disease)
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Critical Care

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