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Table 2 Synthesis of results: surfactant therapy in children

From: Surfactant therapies for pediatric and neonatal ARDS: ESPNIC expert consensus opinion for future research steps

  1. Boxes were colored in green or red if, for a given outcome, the surfactant treatment had a positive effect or not, respectively. Boxes were left blank where no data were available. No studies reported any biochemical or biophysical parameter
  2. Trend which does not reach significance threshold
  3. °A further article is not considered, since it was a post hoc analysis of a subgroup enrolled in one of these trials [44]
  4. *This trial investigated the administration of surfactant following recruitment maneuver versus standard care
  5. Abbreviations: MOFS: multi-organ failure syndrome; PICU: pediatric intensive care unit