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Table 1 Demographics and clinical characteristics of healthy donors and 2 groups of COVID-19 patients

From: Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients

Characteristic

HD

Severity

 

P value (HD vs. Mild)

P value (Mild vs. Severe)

  

Mild

Severe

  

Patient amount

25

94

41

–

–

Age (years)

42 (32, 69)

34.9 ± 15.0

61.8 ± 16.7

0.001

 < 0.001

Male sex, n (%)

15 (60)

43 (45.7)

26 (63.4)

0.607

0.059

Complications, n (%)

 Hypertension

0

6 (6.4)

16 (39.0)

–

 < 0.001

 Cardiovascular disease

0

0

5 (12.2)

–

0.001

 Chronic pulmonary disease

0

2 (2.1)

9 (22.0)

–

 < 0.001

 Diabetes

0

1 (1.1)

10 (24.4)

–

 < 0.001

 Hyperlipemia

0

1 (1.1)

2 (4.9)

–

0.167

 Chronic kidney disease

0

1 (1.1)

4 (9.8)

–

0.014

 Immune disorders

0

0

3 (7.3)

–

0.008

 Others

0

1 (1.1)

1 (2.4)

–

0.543

Hospitalization Period (days)

0

25.5 (17.3, 35.7)

36 (22, 43)

–

0.004

SOFA score

–

0 (0, 0)

2 (0, 3.5)

–

 < 0.001

APACHE II score

–

–

14 (9, 15)

–

–

Laboratory data at admission

 WBC (× 109/L)

6.1 ± 1.1

4.8 (4.1, 6.5)

6.7 (4.8, 8.9)

0.007

 < 0.001

 Lymphocyte (× 109/L)

2.2 (2.0, 2.6)

1.6 (1.2, 2.0)

1.0 (0.8, 1.4)

 < 0.001

 < 0.001

 Neutrophil (× 109/L)

3.4 ± 0.8

2.7 (2.1, 3.8)

5.2 (3.3, 7.9)

0.045

 < 0.001

 Monocyte (× 109/L)

0.4 ± 0.1

0.3 (0.2, 0.4)

0.3 (0.2, 0.4)

0.006

0.429

 Hemoglobin (g/L)

140.6 ± 13.4

137.5 ± 14.4

121.4 ± 18.9

0.431

 < 0.001

 Platelets (× 109/L)

248.1 ± 41

230.5 (182, 278.3)

214 (153, 296)

0.180

0.277

 D-dimer (mg/L)

–

0.3(0.1, 0.4)

1.1 (0.6, 2.2)

–

 < 0.001

 CRP (mg/L)

–

1.6 (0.6, 9.4)

47.1 (24.7, 105.3)

–

 < 0.001

 LDH (U/L)

–

195.5 (172.8, 227.6)

341.1 (296.3, 474.5)

–

 < 0.001

 CK (U/L)

–

69.1 (46.4, 105.4)

110.1 (48.1, 175.4)

–

0.049

 ALT (U/L)

–

19.5 (14, 30.2)

30.4 (17.8, 47.5)

–

0.008

 AST (U/L)

–

20.2 (15.7, 27)

33.7 (22.1, 51.5)

–

 < 0.001

 TBIL (umol/L)

–

9.6 (7.4, 14.3)

11.7 (8, 17.5)

–

0.171

 DBIL (umol/L)

–

3.4 (2.4, 4.7)

4.6 (3.5, 8.7)

–

0.001

 BUN (mmol/L)

–

4.3 ± 1.1

4.4 (3.7, 6.3)

–

0.439

 sCr (umol/L)

–

66.1 (53.4, 78.2)

69.0 (52.8, 84.5)

–

0.470

 GFR (ml/min/1.73m2)

–

110.9 (99.1, 126.9)

94.2 ± 21.8

–

 < 0.001

  1. Data were presented as mean ± standard deviation or as median (interquartile range) for continuous variables and number (%) for categorical variables. The different characteristics between two groups were tested by one-way t tests (normally distributed continuous variables), Mann Whitney nonparametric test (nonnormally distributed variables) or Chi-square test (categorical variables). A two-sided α of less than 0.05 was considered statistically significant
  2. Abbreviations: SOFA score, sequential organ failure assessment score; APACHE II score, acute physiology and chronic health evaluation II score; WBC, white blood cells; CRP, C-reactive protein; LDH, lactate dehydrogenase; CK, creatine kinase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TBIL, total bilirubin; DBIL, direct bilirubin; BUN, blood urea nitrogen; sCr, serum creatinine; GFR, glomerular filtration rate
  3. P < 0.05 was considered statistically significant and is shown in bold
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Critical Care

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