Fig. 8
From: Identification and characterization of neutrophil heterogeneity in sepsis
Schematic illustration of the mechanism of inhibitory neutrophils mediating immunosuppression. Single-cell RNA sequencing confirmed that neutrophils were divided into multiple subclusters in sepsis. LPS mediates PD-L1 expression through p38α-MSK1/-MK2 pathway in neutrophils, and the subsets of highly expressed PD-L1 exert immunosuppressive function, including inducing T cell trans-differentiation, promoting T cell apoptosis and inhibiting T cell activation