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Table 3 High-resolution manometry characteristics of critically ill patients

From: Characterization of esophageal motor activity, gastroesophageal reflux, and evaluation of prokinetic effectiveness in mechanically ventilated critically ill patients: a high-resolution impedance manometry study

Variable (unit)

Critically ill patients

n = 16

Normal range for 5 mL wet swallows (ref. 8 and 9)

Dynamic (swallow) esophageal parameters

  

  Distal contractile integral (mmHg cm s)

3852 (1700–7730)

 > 450 and < 20% more than 8000

  Failed esophageal peristalsis ( %, median/IQR)

73 (54–89)

 < 20

  Panesophageal pressurization (% median/IQR)

64 (48–79)

 < 20

  Double-peaked waves (% median/IQR)

30 (0–50)

 ≤ 15

  Premature contraction (% median/IQR)

20 (2–32)

 < 20

  Rapid contraction (% median/IQR)

5 (0–12)

 < 20

Dynamic (swallow) EGJ parameters

  

  Integrated relaxation pressure (mmHg, median/IQR)

16 (6–21)

 < 15

  Intrabolus pressure (mmHg, median/IQR)

23 (17–28)

 < 17

Static (rest) EGJ parameters

  

  LES tone (mmHg, median/IQR)

18 (9–26)

13–43

  EGJ-CI (mmHg cm, median/IQR)

40 (28–60)

25–55

  Inspiration EGJ pressure (mmHg, median/IQR)

36 (29–42)

29–43

  Expiration EGJ pressure (mmHg, median/IQR)

24 (19–33)

9–20

  Hiatal hernia presence (%)

19

  1. Normative data from healthy volunteers (ref. 8 and 9) are derived from measurements during water-swallowed induced esophageal contraction, whereas dry swallows or spontaneous contractions are analyzed in critically ill patients. Since quantitative differences in peristaltic variables exist between peristalsis associated with wet versus dry swallows, caution is needed when comparing them directly
  2. LES lower esophageal sphincter, EGJ esophagogastric junction, EGJ-CI esophagogastric junction contractile integral