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Table 3 Summary of perioperative fluids administered in the included studies

From: Association between perioperative fluid administration and postoperative outcomes: a 20-year systematic review and a meta-analysis of randomized goal-directed trials in major visceral/noncardiac surgery

Study Total intraoperative fluid administration Total perioperative
Fluid administration (95% CI)
Colloids (ml) (95% CI/SD) Crystalloids (ml) (95% CI/SD) Intraoperative blood (ml)
GDT Controls GDT Controls GDT Controls GDT Controls
Conway [41] 1960 (NA) 1325 (NA) NA NA NA NA 4522 (NA) 3770 (NA)
Wakeling [42] 2000 (NA)* 1500 (NA) 3000 (NA) 3000 (NA) NA NA 5000 (NA) 4500 (NA)
Pearse [30] 1907 (NA)* 930 (NA) 1204 (NA) 960 (NA) 125 (0–734) 0 (0–485) 2837 (NA) 2164
Lobo [26] NA NA NA NA 713 (458) 609 (244) 7447 (NA) 6877 (NA)
Donati [31] 1940 (673) 1805 (611) NA NA 260 (130) 271 (173) 4131 (NA) 4014 (NA)
Benes [25] 1425 (1000–1500) 1000 (540–1250) 2321 (1640–3002) 2459 (1529–3389) 0 (0–500) 270 (0–578) 5333 (NA) 4987 (NA)
Mayer [43] 1188 (638–1738)* 817 (350–1284) 2489 (1684–3294) 3153 (1889–4417)* NA NA 4528 (2211–6845) 4494 (2933–6055)
Brandstrup [32] 810 (NA)* 475 (NA) 483 (NA) 443 (NA) 78 (278) 77 (407) 6144 (NA) 5909 (NA)
Salzwedel [27] 773 (109–1437) 724 (4–1444) 2862 (1646–4078) 2680 (1526–3834) 145 (371) 224 (1036) 7053 (NA) 7597(NA)
McKenny [44] 1000 (1000–1500)* 500 (0–1000) 1000 (787–1750) 2000 (1725–2500)* NA NA 2620 (NA) 2881 (NA)
Scheeren [28] 1589 (1150–2028) 927 (631–1223) NA NA 319 (495) 685 (832) 4477 (3740–5214) 4528 (3693–5363)
Srinivasa [45] 591 (471) 297 (275) NA NA NA NA 5744 (NA) 4014 (NA)
Pearse [19] 1250 (1000–2000) 500 (0–1000) 1000 (459–2000) 2000 (1283–3000) NA NA 3256 (NA) 3100 (NA)
Phan [46] 500 (250–750)* 0 (0–300) 1500 (1000–2000) 1400 (1000–2000) NA NA 4470 (NA) 3916 (NA)
Ackland [47] 500 (0–1000) 625 (0–1438) 3000 (2000–4000) 3000 (2000–4000) NA NA 5000 (NA) 4748 (NA)
Correa-Gallego [48] NA NA NA NA NA NA 3800 (NA) 4500 (NA)
Weinberg [34] 200 (500–700) 200 (175–550) 1875 (1000–2000) 4000 (2313–4206)* NA NA 4516 (NA) 7034 (NA)
Gomez-Izquierdo [49] 500 (323–687) 2102 (1600–2528)* 900 (400–1400)* 0 (0–500) NA NA 1819 (NA) 2914 (NA)
Wu [50] 900 (400–1400)* 0 (0–500) 500 (323–687) 2102 (1600–2528) NA NA 1535 (1000–2272) 2370 (1779–3071)
Zhao [33] 775 (539–1011)* 487 (435–539) 471 (371–571) 459 (427–491) 885 (377) 443 (140) 1478 (1167–1790) 1183 (1120–1246)
Weinberg yyy[29] 200 (500–700) 200 (175–550) 1875 (1000–2000) 2000 (1125–2000) 356 (248–465) 465 (465–465) 4950 (NA) 4450 (NA)
  1. NA, data not available; GDT, patients’ subgroup receiving goal-directed therapy; ml, milliliters. Data are reported including 95% confidence interval (95%CI) or standard deviation (SD), as appropriate; when NA is present after a value, it implies a computation of available data reported in the paper. Perioperative fluid therapy reports the overall amount of fluid includes the fluid infused during the operation and within the first 24 h in the critically ill area. * = difference reported in the study as statistically significant among GDT/controls subgroups regarding intraoperative colloids or crystalloids administration