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Table 1 Summary of the included GDT studies

From: Association between perioperative fluid administration and postoperative outcomes: a 20-year systematic review and a meta-analysis of randomized goal-directed trials in major visceral/noncardiac surgery

First author Year Surgery Pt. Enrolled
n
Pt. Analyzed
n (%)
GDT
n (%)
Controls
n (%)
ASA I n (%) ASA II n (%) ASA III-IV n (%)
GDT Controls GDT Controls GDT Controls
Conway [41] 2002 Abdominal surgery 57 57 (100) 29 (50.9) 28 (49.1) NA NA NA NA NA NA
Wakeling [42] 2005 Abdominal surgery 178 128 (71.9) 64 (50) 64 (50) NA NA NA NA NA NA
Pearse [30] 2005 Mixed 160 122 (76.3) 62 (50.8) 60 (49.2) NA NA NA NA NA 60 (100)
Lobo [26] 2006 Mixed 72 50 (69.4) 25 (50) 25 (50) NA NA NA NA NA NA
Donati [31] 2007 Mixed 324 135 (41.7) 68 (50.4) 67 (49.6) 0 (0.0) 0 (0.0) 9 (13.3) 11 (16.4) 59 (86.8) 56 (83.6)
Benes [25] 2010 Mixed 215 105 (48.8) 51 (48.6) 54 (51.4) 0 (0.0) 0 (0.0) 14 (23.3) 11 (18.3) 46 (76.4) 49 (81.7)
Mayer [43] 2010 Abdominal surgery 102 60 (58.8) 30 (50) 30 (50) NA NA NA NA 30 (100) 30 (100)
Brandstrup [32] 2012 Abdominal surgery 185 150 (81.1) 71 (47.3) 79 (52.7) 26 (37) 20 (25) 37 (52) 43 (54) 8 (11) 16 (20)
Salzwedel [27] 2013 Mixed 180 160 (88.9) 79 (49.4) 81 (50.6) NA NA NA NA 33 (41.3) 33 (40.7)
McKenny [44] 2013 Gynecological surgery 113 101 (89.4) 51 (50.5) 50 (49.5) NA NA NA NA NA NA
Scheeren [28] 2013 Mixed 64 52 (81.3) 26 (50) 26 (50) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 26 (100) 26 (100)
Srinivasa [45] 2013 Abdominal surgery 98 74 (75.5) 37 (50) 37 (50) 5 (13) 5 (13.5) 20 (54) 15 (40.5) 12 (32) 17 (46)
Pearse [19] 2014 Mixed 1735 734 (42.3) 368 (50.1) 366 (49.9) 21 (5.7) 24 (6.6) 201 (54.5) 176 (48.1) 146 (39.8) 166 (45.3)
Phan [46] 2014 Abdominal surgery 131 100 (76.3) 50 (50) 50 (50) NA NA NA NA NA NA
Ackland [47] 2015 Mixed 204 187 (91.7) 95 (50.8) 92 (49.2) NA NA NA NA NA NA
Correa-Gallego [48] 2015 Abdominal surgery 468 135 (28.8) 69 (51.1) 66 (48.9) NA NA NA NA NA NA
Weinberg [34] 2017 Abdominal surgery 68 52 (76.5) 26 (50) 26 (50) NA NA NA NA NA NA
Gomez-Izquierdo [49] 2017 Abdominal surgery 196 128 (65.3) 64 (50) 64 (50) 6 (9) 8 (12) 42 (66) 38 (60) 16 (25) 18 (28)
Wu [50] 2017 Neurological surgery 111 63 (56.8) 33 (52.4) 30 (47.6) 13 (40) 9 (30) 20 (60) 21 (70) 0 (0.0) 0 (0.0)
Zhao [33] 2018 Abdominal surgery 88 88 (100) 44 (50) 44 (50) NA NA 31 (70) 29 (66.6) 13 (30) 15 (33.1)
Weinberg [29] 2019 Abdominal surgery 61 48 (78.7) 24 (50) 24 (50) NA NA NA NA 18 (75) 21 (88)
  1. Pt., patients; N; number of patients; NA, data not available; ASA, American Society of Anesthesiologists physical status; GDT, goal-directed therapy