Fig. 4

Pooled diagnostic AUC for either ∆BNP or ∆BNP% methods of measurements, in studies that included SBT failure (group 1) and studies that excluded SBT failure (group 2) from liberation failure analysis. These figures illustrate the individual AUC obtained from the studies for each method of BNP measurement separately (DBNP and DBNP%). Both studies that included SBT failure (group 1) and excluded SBT failure (group 2) in liberation failure analysis were included to increase statistical power. The pooled AUC for DBNP% showed a high AUC with low heterogeneity, while the pooled AUC for DBNP showed a high AUC with moderate heterogeneity