Fig. 1 (abstract P509).

Relationship between vasopressor exposure and limb or digit threat following vasopressor-dependent sepsis. Panel A demonstrates the estimated contribution of daily vasopressor intensity prior to surgical evaluation for limb or digit threat, with mortality as a competing risk. Panel B and C explore the relationship between threat and both cumulative vasopressor exposure and the pattern of exposure following sepsis onset. (B) The maximum cumulative vasopressor exposure was associated with the highest risk of limb or digit threat (SHR 17.5) when compared to reference exposure pattern (SHR 1.0, reference). (C) Increasing (SHR 1.2) and peak (SHR 1.2) patterns of cumulative exposure were associate with an increased SH of limb threat, while a decreasing pattern was associated with a lower risk (SHR 0.8) when compared to constant intensity (SHR 1.0, reference). Abbreviations: SHR: Sub-distribution hazard ratio