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Table 4 Comparison between 43 and 14 sample protocols

From: Lactate kinetics in ICU patients using a bolus of 13C-labeled lactate

 N = 43N = 14p
AUCtot [% × min]130 ± 55132 ± 570.054
AUCextrap [% × min]10.0 ± 6.010.3 ± 7.20.538
λz 70 [min−1]− 0.015 ± 0.006− 0.015 ± 0.0060.748
Ra [μmol/kg/min]15.8 (8.5–44.2)15.8 (8.3–44.2)0.404
  1. Mean ± SD or median (range) for all subjects (healthy volunteers and ICU patients). Differences between protocols are analyzed by paired t test or Wilcoxon test for nonparametric data. AUCtot area under the curve, AUCextrap the part of AUC that is beyond the last measurement point, λz 70 terminal slope as calculated from t = 70 min, Ra rate of appearance of lactate. Details of the pharmacokinetic non-compartmental modeling are presented in Additional file 1