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Table 4 Comparison between 43 and 14 sample protocols

From: Lactate kinetics in ICU patients using a bolus of 13C-labeled lactate

 

N = 43

N = 14

p

AUCtot [% × min]

130 ± 55

132 ± 57

0.054

AUCextrap [% × min]

10.0 ± 6.0

10.3 ± 7.2

0.538

λz 70 [min−1]

− 0.015 ± 0.006

− 0.015 ± 0.006

0.748

Ra [μmol/kg/min]

15.8 (8.5–44.2)

15.8 (8.3–44.2)

0.404

  1. Mean ± SD or median (range) for all subjects (healthy volunteers and ICU patients). Differences between protocols are analyzed by paired t test or Wilcoxon test for nonparametric data. AUCtot area under the curve, AUCextrap the part of AUC that is beyond the last measurement point, λz 70 terminal slope as calculated from t = 70 min, Ra rate of appearance of lactate. Details of the pharmacokinetic non-compartmental modeling are presented in Additional file 1
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Critical Care

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