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Table 3 Comparison for lactate kinetic parameters between volunteers and ICU patients by non-compartmental analysis

From: Lactate kinetics in ICU patients using a bolus of 13C-labeled lactate

 Volunteers (n = 6)ICU patients (n = 10)p
AUC total [% × min]172 ± 50105 ± 430.021
AUCextrap [% × min]11.6 ± 7.89.0 ± 4.90.474
AUCextrap [% of AUC total]6.7 ± 4.29.7 ± 7.00.300
Ra [μmol/kg/min]12.8 ± 3.922.7 ± 11.10.025
Ra [mmol/min]1.1 ± 0.51.8 ± 0.90.067
Metabolic clearance [L/min]1.56 ± 0.391.12 ± 0.430.058
Plasma lactate [mmol/L]0.7 (0.4–0.9)1.4 (0.6–4.9)0.065
AUMC total [% × min2]5138 ± 23503899 ± 13580.263
MRT [min]25.8 (21.6–51.2)33.3 (22.8–82.2)0.076
Vss [L]45.4 ± 14.042.0 ± 14.70.649
Vc [L]9.6 ± 2.59.7 ± 3.00.937
  1. Values are presented as means ± standard deviation or medians (range) as appropriate according to Shapiro Wilk’s normality test. p values refer to unpaired two-sided t test with Welch’s correction (not assuming the same standard deviation in both groups) or Mann-Whitney test for nonparametric data. AUC area under the curve, AUCextrap the part of AUC that is beyond the last measurement point, Ra rate of appearance, AUMC area under the first moment curve, MRT mean residence time, Vss volume of distribution at steady state, Vc central volume of distribution. Details of the pharmacokinetic non-compartmental modeling are presented in Additional file 1