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Table 3 Comparison for lactate kinetic parameters between volunteers and ICU patients by non-compartmental analysis

From: Lactate kinetics in ICU patients using a bolus of 13C-labeled lactate

 

Volunteers (n = 6)

ICU patients (n = 10)

p

AUC total [% × min]

172 ± 50

105 ± 43

0.021

AUCextrap [% × min]

11.6 ± 7.8

9.0 ± 4.9

0.474

AUCextrap [% of AUC total]

6.7 ± 4.2

9.7 ± 7.0

0.300

Ra [μmol/kg/min]

12.8 ± 3.9

22.7 ± 11.1

0.025

Ra [mmol/min]

1.1 ± 0.5

1.8 ± 0.9

0.067

Metabolic clearance [L/min]

1.56 ± 0.39

1.12 ± 0.43

0.058

Plasma lactate [mmol/L]

0.7 (0.4–0.9)

1.4 (0.6–4.9)

0.065

AUMC total [% × min2]

5138 ± 2350

3899 ± 1358

0.263

MRT [min]

25.8 (21.6–51.2)

33.3 (22.8–82.2)

0.076

Vss [L]

45.4 ± 14.0

42.0 ± 14.7

0.649

Vc [L]

9.6 ± 2.5

9.7 ± 3.0

0.937

  1. Values are presented as means ± standard deviation or medians (range) as appropriate according to Shapiro Wilk’s normality test. p values refer to unpaired two-sided t test with Welch’s correction (not assuming the same standard deviation in both groups) or Mann-Whitney test for nonparametric data. AUC area under the curve, AUCextrap the part of AUC that is beyond the last measurement point, Ra rate of appearance, AUMC area under the first moment curve, MRT mean residence time, Vss volume of distribution at steady state, Vc central volume of distribution. Details of the pharmacokinetic non-compartmental modeling are presented in Additional file 1
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Critical Care

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