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Table 2 Comparison of response to naloxone vs combined buprenorphine groups (n = 81)

From: Buprenorphine to reverse respiratory depression from methadone overdose in opioid-dependent patients: a prospective randomized trial

OutcomeNaloxone (n = 27)Buprenorphine (n = 54)P value
Response to bolus antidote dosesComplete 13 (48%)
Partial 13 (48%)
No response 1(4%)
Complete 50 (93%)
Partial 3 (5%)
No response 1 (2%)
< 0.0001
Opioid withdrawal15 (56%)6 (11%)< 0.0001
Further apnea6 (22%)7 (13%)0.34
Aspiration1 (4%)6 (11%)0.41
Intubation8 (30%)5 (9%)0.026
Continuing Sedation9 (33%)3 (6%)0.002
ARDS4 (15%)00.01
Discharged alive with no sequelae (%)23 (85%)54 (100%)0.01