Table 2 Comparison of response to naloxone vs combined buprenorphine groups (n = 81)
Outcome | Naloxone (n = 27) | Buprenorphine (n = 54) | P value |
|---|---|---|---|
Response to bolus antidote doses | Complete 13 (48%) Partial 13 (48%) No response 1(4%) | Complete 50 (93%) Partial 3 (5%) No response 1 (2%) | < 0.0001 |
Opioid withdrawal | 15 (56%) | 6 (11%) | < 0.0001 |
Further apnea | 6 (22%) | 7 (13%) | 0.34 |
Aspiration | 1 (4%) | 6 (11%) | 0.41 |
Intubation | 8 (30%) | 5 (9%) | 0.026 |
Continuing Sedation | 9 (33%) | 3 (6%) | 0.002 |
ARDS | 4 (15%) | 0 | 0.01 |
Discharged alive with no sequelae (%) | 23 (85%) | 54 (100%) | 0.01 |