Table 1 Population characteristics
Total population (n = 27) | IH (n = 14) | No-IH (n = 13) | p* | |
|---|---|---|---|---|
Age, median [IQR] | 46 [36–55] | 46 [36–50] | 46 [37–56] | 0.981 |
Female, n (%) | 5 (18.5%) | 2 (14.3%) | 3 (23.1%) | 0.648 |
BMI, median [IQR] | 26 [23–31] | 26 [22–30] | 26 [23–33] | 0.601 |
Traumatic brain injury, n (%) | 10 (37.0%) | 6 (42.9%) | 4 (30.8%) | 0.694 |
Subarachnoid haemorrhage, n (%) | 11 (40.7%) | 5 (35.7%) | 6 (46.1%) | 0.703 |
Haemorrhagic stroke, n (%) | 7 (25.9%) | 4 (28.6%) | 3 (23.1%) | 1.000 |
Ischemic stroke, n (%) | 1 (3.7%) | 0 (0%) | 1 (7.7%) | 0.481 |
Aspiration pneumonia, n (%) | 13 (48.1%) | 7 (50.0%) | 6 (46.1%) | 1.000 |
Ventilator-associated pneumonia, n (%) | 14 (51.8%) | 7 (50.0%) | 7 (53.8%) | 1.000 |
Severity | ||||
SAPSII, median [IQR] | 42 [34–53] | 47 [41–55] | 39 [30–46] | 0.076 |
Glasgow Coma Scale at intubation, median [IQR] | 6 [4–8] | 6 [4–8] | 6 [4–7] | 0.769 |
First ICP measure, median [IQR] | 22 [12–29] | 24 [19–37] | 16 [8–26] | 0.274 |
IH treatment | ||||
Craniectomy, n (%) | 3 (11.1%) | 1 (7.1%) | 2 (15.4%) | 0.595 |
Hypothermia, n (%) | 5 (18.5%) | 3 (21.4%) | 2 (15.4%) | 1.000 |
Osmotherapy, n (%) | 11 (40.7%) | 7 (50,0%) | 4 (30.8%) | 0.440 |
Thiopental administration, n (%) | 10 (37.0%) | 6 (42.9%) | 4 (30.8%) | 0.694 |
At least one of IH treatment, n (%) | 14 (51.8%) | 8 (57.1%) | 6 (46.1%) | 0.706 |
EVD, n (%) | 14 (51.8%) | 7 (50.0%) | 7 (53.9%) | 1.000 |
ARDS treatment | ||||
Neuromuscular blockade, n (%) | 27 (100%) | 14 (100%) | 13 (100%) | |
PP number, median [IQR] | 1 [1–2] | 1 [1–2] | 1 [1–3] | 0.295 |
Duration of PP (hours), median [IQR] | 14 [9–19] | 13 [8–17] | 16 [11–20] | 0.305 |
First PP delay, median days [IQR] | 5 [4–7] | 6 [5–7] | 5 [4–6] | 0.279 |
Tidal volume mL/kg, median [IQR] | 6.8 [6.4–7.5] | 6.7 [6.4–7.5] | 6.9 [6.4–7.5] | 0.843 |
Parameters before PP | ||||
Initial ICP (mmHg), median [IQR] | 13 [8–20] | 20 [13–26] | 11 [7–12] | 0.005 |
Initial CPP (mmHg), median [IQR] | 75 [66–82] | 67 [64–75] | 79 [77–87] | 0.041 |
Initial PEEP (cmH20), median [IQR] | 10 [9–12] | 10 [9–11] | 10 [9–12] | 0.657 |
Initial FiO2, median (%) [IQR] | 80 [60–89] | 80 [71–100] | 67 [60–81] | 0.231 |
Initial plateau pressure (cmH20), median [IQR] | 23 [21–27] | 23 [21–29] | 23 [21–26] | 0.689 |
Initial PaO2/FiO2, median [IQR] | 100 [89–126] | 99 [88–113] | 109 [93–142] | 0.481 |
Initial PaO2 (mmHg), median [IQR] | 78 [74–95] | 78 [74–90] | 77 [74–99] | 0.903 |
Initial PaCO2 (mmHg), median [IQR] | 43 [37–47] | 43 [38–46] | 44 [36–48] | 0.884 |
Outcome | ||||
Mechanical ventilation duration (days), median [IQR] | 23 [11–36] | 22 [7–35] | 23 [16–37] | 0.395 |
Modified Rankin Scale at ICU discharge, median [IQR] | 4 [4–5] | 4 [4–6] | 4 [4–5] | 0.853 |
Mortality, n (%) | 7 (25.9%) | 4 (28.6%) | 3 (23.1%) | 1.000 |