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Table 2 Results of sensitivity analyses and subgroup analyses

From: Timing of renal replacement therapy initiation for acute kidney injury in critically ill patients: a systematic review of randomized clinical trials with meta-analysis and trial sequential analysis

Group No. of trials No. of patients Risk ratio (95% CI) P value Heterogeneity
I2, % P value for I2
Subgroup analyses
Mean age
  > 65 years 7 [20, 22, 24–26, 29, 30] 1627 0.99 (0.89, 1.11) 0.88 0 0.67
  ≤ 65 years 3 [14, 23, 27] 3251 1.02 (0.93, 1.12) 0.63 0 0.95
SOFA scores at administration
  > 12 3 [22, 24, 27] 819 0.95 (0.75, 1.20) 0.65 31 0.24
  ≤ 12 7 [14, 20, 23, 25, 26, 29, 30] 4059 1.02 (0.94, 1.10) 0.62 0 0.98
Criteria for early RRT initiation
 Approximately equal to stage 2 of the KDIGO classification 4 [14, 24, 27, 29] 3329 1.01 (0.92, 1.10) 0.89 4 0.37
 Approximately equal to stage 3 of the KDIGO classification 2 [20, 22] 1107 1.00 (0.88, 1.15) 0.95 0 0.41
 Other classification criteria 4 [23, 25, 26, 30] 442 1.05 (0.86, 1.29) 0.61 0 0.97
Sensitivity analyses
Publish language (excluding the study published in Chinese) 9 [14, 20, 22–27, 29] 4818 1.01 (0.94, 1.08) 0.81 0 0.85
Risk of bias (only including low risk of bias studies) 8 [14, 20, 22–27] 4747 1.01 (0.94, 1.08) 0.86 0 0.81
Publish year (removing studies published before 2010) 9 [14, 20, 22–27, 30] 4807 1.01 (0.94, 1.08) 0.82 0 0.86
  1. CI confidence interval, SOFA Sequential Organ Failure Assessment