Table 1 Characteristics of patients with and without hemolytic anemia
Hemolytic anemia (94) | Non-hemolytic anemia (93) | p | |
|---|---|---|---|
General characteristics | |||
Age (years) | 47 (32–62) | 69 (59–77) | 0.0004 |
Women (%) | 51 | 33 | 0.004 |
Smokers (%) | 34 | 37 | 0.9 |
SOFA at admission | 6 (3–7) | 6 (4–9) | 0.004 |
Sepsis (%) | 18 | 27 | 0.1 |
Mechanical ventilation (%) | 17 | 57 | < 0.0001 |
Catecholamines (norepinephrine) (%) | 17 | 54 | < 0.0001 |
Extra-renal epuration (%) | 17 | 13 | 0.43 |
Length of stay in ICU (days) | 6 (3–12) | 7 (4–12) | 0.54 |
Mortality (%) | 16 | 32 | 0.24 |
Cause of anemia (%) | |||
Hemolytic anemia (94) | |||
AIHA | 26 | ||
SCD | 20 | ||
TMA | 54 | ||
Non-hemolytic anemia (93) | |||
Bleeding | 37 | ||
Chronic renal failure | 15 | ||
Cytopenia | 23 | ||
Splenomegaly | 10 | ||
Other | 15 | ||
Biological marker (blood) | |||
Hemoglobin (g/dL) | 7.8 (6.2–9.1) | 7.3 (6.5–8.1) | 0.14 |
White blood cells (× 109/L) | 10.6 (7.8–17.9) | 11.3 (6.7–16.5) | 0.2 |
Platelets (10 3/mm3) | 76 (33.2–228) | 141 (48–237) | 0.09 |
Mean corpuscular volume (fL) | 88 (83–93) | 88 (82–94) | 0.47 |
Reticulocytes (G/L) | 134 (77–211) | 55 (29–77) | 0.0001 |
LDH (UI/L) | 1361 (866–2121) | 536 (420–786) | 0.46 |
Unconjugated bilirubin (μmol/L) | 27 (18–45) | 15 (10–20) | < 0.0001 |
Prothrombin time (%) | 76 (62–89) | 70 (57–80) | 0.009 |
Activated partial thromboplastin time ratio | 1.07 (0.94–1.3) | 1.17 (1.01–1.51) | 0.055 |
Creatinine (μmol/L) | 102 (71–160) | 122 (81–206) | 0.47 |
pH | 7.44 (7.4–7.48) | 7.44 (7.34–7.48) | 0.25 |
pO2 (mmHg) | 87 (70–113) | 81 (67–107) | 0.92 |
pCO2 (mmHg) | 34 (31–43) | 35 (30–42) | 0.93 |
Lactate (mmol/L) | 1.3 (0.9–2.5) | 1.25 (0.9–2.3) | 0.88 |
Carboxyhemoglobin (%) | 3.0 (2.3–3.9) | 1.6 (1.0–2.1) | < 0.0001 |
Methemoglobin (%) | 1.5 (1.2–1.8) | 1 (0.7–1.4) | < 0.0001 |