Table 2 Relationship between baseline parameters and EAdi resumption during the study period

Univariate logistic models

 Age (year)

1.03 (1.01–1.05)

69

 Sex (ref. Female)

0.97 (0.58–1.63)

69

Acute Physiologic Assessment and Chronic Health Evaluation (APACHE) II Scoring System (score)

1.02 (0.98–1.06)

68

Body mass index, (kg/m²)

1.02 (0.99–1.05)

67

Mode of ventilation (ref. assisted)

1.79 (0.98–3.26)

69

PaO₂/FiO₂ (mmHg)

1.00 (1.00–1.00)

63

Creatinine (µmol/L)

1.00 (1.00–1.00)

69

Baseline acute kidney injury stage (ref. No acute kidney injury)

69

 1

1.76 (0.96–3.20)

 2

0.87 (0.26–2.89)

 3

1.64 (0.75–3.62)

Baseline bilirubin (µmol/L)

1.00 (0.99–1.01)

68

Cause of intubation (ref. Neurologic)

65*

 Pulmonary

1.14 (0.60–2.18)

 Hemodynamic

0.93 (0.40–2.13)

Sedation analgesia score during the first 6 h (score)

1.19 (0.88–1.60)

54

Use of sedative (ref. No)

0.18 (0.10–0.32)

69

Use of sedative (ref. No)—time dependent

0.09 (0.04–0.21)

69

Use of Propofol (ref. No)

0.34 (0.19–0.60)

69

Use of Propofol (ref. No)—time dependent

0.32 (0.18–0.57)

69

Dose propofol (1 mg/kg)

0.98 (0.96–1.00)

69

Dose propofol (1 mg/kg)—time dependent

0.98 (0.96–0.99)

69

Use of Midazolam (ref. No)

0.29 (0.16–0.52)

69

Use of Midazolam (ref. No)—time dependent

0.29 (0.15–0.55)

69

Dose midazolam (0.01 mg/kg)

1.00 (0.99–1.00)

69

Dose midazolam (0.01 mg/kg)—time dependent

0.96 (0.91–1.00)

69

Use of Fentanyl (ref. No)

0.36 (0.21–0.62)

69

Use of Fentanyl (ref. No)—time dependent

0.36 (0.20–0.64)

69

Dose fentanyl (1 mcg/kg)

0.99 (0.97–1.00)

69

Dose fentanyl (1 mcg/kg)—time dependent

0.98 (0.96–0.99)

69

Neuromuscular blocking agent use (ref. No)

0.78 (0.43–1.43)

69

Multivariable model with time dependent variables

Model 1

 Use of sedative (ref. No)—time dependent

0.09 (0.04–0.21)

69

Model 2

 Use of Midazolam (ref. No)—time dependent

  Without propofol

0.49 (0.22–1.10)

  With propofol

0.11 (0.05–0.26)

Multivariable model (no time dependent variables)

Model 1

 Use of sedative (ref. No)

0.18 (0.10–0.32)

69

Model 2

69

 Use of Midazolam (ref. No)

0.31 (0.17–0.566)

 Use of Propofol (ref. No)

0.38 (0.21–0.67)