Skip to main content

Table 2 Relationship between baseline parameters and EAdi resumption during the study period

From: Duration of diaphragmatic inactivity after endotracheal intubation of critically ill patients

  Hazard ratio (95% confidence interval) p value Patients
Univariate logistic models
 Age (year) 1.03 (1.01–1.05) 0.0022 69
 Sex (ref. Female) 0.97 (0.58–1.63) 0.9179 69
Acute Physiologic Assessment and Chronic Health Evaluation (APACHE) II Scoring System (score) 1.02 (0.98–1.06) 0.2900 68
Body mass index, (kg/m2) 1.02 (0.99–1.05) 0.1771 67
Mode of ventilation (ref. assisted) 1.79 (0.98–3.26) 0.0587 69
PaO2/FiO2 (mmHg) 1.00 (1.00–1.00) 0.3537 63
Creatinine (µmol/L) 1.00 (1.00–1.00) 0.2590 69
Baseline acute kidney injury stage (ref. No acute kidney injury)    69
 1 1.76 (0.96–3.20) 0.0665  
 2 0.87 (0.26–2.89) 0.8155  
 3 1.64 (0.75–3.62) 0.2178  
Baseline bilirubin (µmol/L) 1.00 (0.99–1.01) 0.8071 68
Cause of intubation (ref. Neurologic)    65*
 Pulmonary 1.14 (0.60–2.18) 0.6904  
 Hemodynamic 0.93 (0.40–2.13) 0.8578  
Sedation analgesia score during the first 6 h (score) 1.19 (0.88–1.60) 0.2639 54
Use of sedative (ref. No) 0.18 (0.10–0.32) < .0001 69
Use of sedative (ref. No)—time dependent 0.09 (0.04–0.21) < .0001 69
Use of Propofol (ref. No) 0.34 (0.19–0.60) 0.0002 69
Use of Propofol (ref. No)—time dependent 0.32 (0.18–0.57) 0.0001 69
Dose propofol (1 mg/kg) 0.98 (0.96–1.00) 0.0334 69
Dose propofol (1 mg/kg)—time dependent 0.98 (0.96–0.99) 0.0029 69
Use of Midazolam (ref. No) 0.29 (0.16–0.52) < .0001 69
Use of Midazolam (ref. No)—time dependent 0.29 (0.15–0.55) 0.0002 69
Dose midazolam (0.01 mg/kg) 1.00 (0.99–1.00) 0.1018 69
Dose midazolam (0.01 mg/kg)—time dependent 0.96 (0.91–1.00) 0.0603 69
Use of Fentanyl (ref. No) 0.36 (0.21–0.62) 0.0002 69
Use of Fentanyl (ref. No)—time dependent 0.36 (0.20–0.64) 0.0004 69
Dose fentanyl (1 mcg/kg) 0.99 (0.97–1.00) 0.1540 69
Dose fentanyl (1 mcg/kg)—time dependent 0.98 (0.96–0.99) 0.0125 69
Neuromuscular blocking agent use (ref. No) 0.78 (0.43–1.43) 0.4262 69
Multivariable model with time dependent variables    
Model 1    
 Use of sedative (ref. No)—time dependent 0.09 (0.04–0.21) < .0001 69
Model 2    
 Use of Midazolam (ref. No)—time dependent    
  Without propofol 0.49 (0.22–1.10) 0.0799  
  With propofol 0.11 (0.05–0.26) < .0001  
Multivariable model (no time dependent variables)    
Model 1    
 Use of sedative (ref. No) 0.18 (0.10–0.32) < .0001 69
Model 2    69
 Use of Midazolam (ref. No) 0.31 (0.17–0.566) 0.0001  
 Use of Propofol (ref. No) 0.38 (0.21–0.67) 0.0009