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Table 1 Characteristics of the fluids assessed and qualitative summary from this network meta-analysis

From: Resuscitation fluid types in sepsis, surgical, and trauma patients: a systematic review and sequential network meta-analyses

Components Plasma Balanced crystalloid Saline Albumin (Iso-/Hyperoncotic) L-HES Gelatin
Osmolarity (mOsm/kg) 291 Hypotonic (254–273) Isotonic (286) Hypotonic (4%, 260; 5%, 250; 20%, 200; 25%, 250) Isotonic to Hypertonic (283–304) Isotonic to Hypertonic (274–301)
Na/Cl (mmol/l) 140/103 130–140/98–111 154/154 130–160/128–130 137–154/110–154 145–154/120–145
K/Ca (mmol/l) 40/4 4–5/2–2.7 0/0 < 2/0 0–4/0–2.5 0–5.1/0–6.25
Conditions Outcome Balanced crystalloid Saline Albumin L-HES Gelatin
Sepsis NMA results Lowest mortality
Lowest acute kidney injury
Lowest transfusion volume
More fluid volume required
Higher mortality
More fluid volume required
Lower mortality (Iso-oncotic)
Least fluid volume required
Highest mortality
More acute kidney injury
More transfusion volume
 
Comments Fluid of choice for sepsis Not favored for sepsis Iso-oncotic albumin for sepsis patients with risk of fluid overload Not favored for sepsis Require further trials
Surgery NMA results Most fluid volume required
Lower acute kidney injury
More fluid volume required
More blood transfusion volume
Lower mortality (Hyper-oncotic)
Less fluid volume required
Less acute kidney injury
Less blood transfusion volume
Highest mortality
Less fluid volume required
Less fluid volume required
Comments More favored for surgery Less favored for surgery Favored for surgery Not favored for surgery Require further trials
Trauma Mortality Lower mortality
Less acute kidney injury
Less transfusion volume
More fluid volume required
Lower mortality
More acute kidney injury
More transfusion volume
Higher mortality
Less acute kidney injury
Less transfusion volume
Higher mortality  
Comments More favored for trauma Damage control resuscitation. May consider blood products for resuscitation    
Traumatic brain injury (TBI) Mortality Higher mortality Lower mortality Highest mortality (Iso-oncotic) Lowest mortality  
Comments Hypotonic solution was not suggested for TBI Favored for TBI Iso-oncotic albumin with hypotonic solution was not favored for TBI May consider for TBI Require further trials