|
Per-protocol 2 h
| | | |
|
PaCO2 (mmHg) on patients who completed the treatment originally allocated at 2 h, mean ± SD
| | | |
|
Subjects, n
|
34
|
37
|
–
|
|
At baseline ( T0)
|
74.0 ± 13.5
|
72.2 ± 13.3
|
0.5845
|
|
After 2 h ( T2h )
|
67.2 ± 16.4
|
62.7 ± 13.5
|
0.1933
|
|
After 6 h ( T6h )
|
64.5 ± 15.8
|
57.9 ± 12.2
|
0.0630
|
|
ΔT2h − T0
|
− 6.8 ± 8.7
|
− 9.5 ± 8.5
|
0.4040
|
|
ΔT6h − T0
|
− 9.5 ± 13.0
|
− 14.3 ± 11.1
|
0.0962
|
|
ΔT6h − T2h
|
− 2.7 ± 9.7
|
− 4.8 ± 7.1
|
0.1637
|
|
Per-protocol 6 h
| | | |
|
PaCO2 (mmHg) on patients who completed the treatment originally allocated at 6 h, mean ± SD
| | | |
|
Subjects, n
|
24
|
29
|
−
|
|
At baseline ( T0)
|
72.7 ± 10.3
|
74.0 ± 13.7
|
0.7955
|
|
After 2 h ( T2h )
|
64.7 ± 8.7
|
63.7 ± 14.5
|
0.7493
|
|
After 6 h ( T6h )
|
61.4 ± 7.7
|
59.8 ± 12.6
|
0.5632
|
|
ΔT2h − T0
|
− 8.0 ± 6.5
|
− 10.3 ± 8.9
|
0.5200
|
|
ΔT6h − T0
|
− 11.3 ± 7.3
|
− 14.2 ± 12.0
|
0.4475
|
|
ΔT6h − T2h
|
− 3.3 ± 6.9
|
− 3.9 ± 7.6
|
0.8163
|
|
Intention-to-treat analysis
| | | |
|
PaCO2 (mmHg) of enrolled patients, mean ± SD
| | | |
|
Subjects, n
|
40
|
39
| |
|
At baseline ( T0)
|
73.7 ± 12.8
|
72.0 ± 13.0
|
0.5270
|
|
After 2 h ( T2h )
|
68.2 ± 15.6
|
63.4 ± 13.6
|
0.1387
|
|
After 6 h ( T6h )
|
64.0 ± 14.9
|
58.1 ± 12.4
|
0.0610
|
|
ΔT2h − T0
|
− 5.5 ± 9.3
|
− 8.6 ± 9.3
|
0.2940
|
|
ΔT6h − T0
|
− 9.7 ± 13.2
|
− 13.9 ± 11.3
|
0.1329
|
|
ΔT6h − T2h
|
− 4.2 ± 11.1
|
− 5.3 ± 7.5
|
0.3670
|
