From: SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review
Mechanisms of SARS-CoV-2 receptor binding |
---|
SARS-CoV-2: similar receptor-binding domain structure to SARS-CoV [20] |
SARS-CoV-2 uses angiotensin-converting enzyme 2 to target cells [1] |
SARS-CoV-2 and SARS-CoV S protein affinity to angiotensin-converting enzyme 2: similar [21] or ~ 10- to 20-fold higher [22] |
SARS-CoV-2 S protein: requires transmembrane protease serine 2 for S protein priming [26] |
SARS-CoV-2 S protein: furin-like protease recognition pattern [25] |
Soluble recombinant human ACE2 can inhibit SARS-CoV-2 infections [27] |
COVID 19 patients: Greater number of angiotensin-converting enzyme 2-positive lung endothelial cells compared with uninfected controls [29] |