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Fig. 6 | Critical Care

Fig. 6

From: Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study

Fig. 6

a Typical images showing microglial morphology from sham, TBI control and TBI xenon. i In the left hippocampal CA3, smaller more round (resting) microglia predominate in all groups with increased numbers in xenon-treated group. ii In the right somatosensory cortex (S1BF), smaller more round (resting) microglia predominate in the sham and control TBI groups, while in the xenon TBI group there is an increase in number of larger less ramified and less round (active) microglia. The scale bars are 20 μm and applies to all images. b Quantification of resting and active microglia in i left hippocampal CA1, ii CA3, iii DG, iv right S1BF and v left hypothalamus. The lines are medians, boxes represent interquartile interval and whiskers are range. n = 6 sham (white boxes); n = 6, TBI control (blue boxes); n = 5 TBI xenon (red boxes) * p < 0.05, ** p < 0.01, *** p < 0.001, compared to sham group as indicated by brackets, Kruskal Wallis test with Benjamini Yekutieli correction

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Critical Care

ISSN: 1364-8535