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Table 1 Baseline characteristics of the study population

From: Myoglobin clearance with continuous veno-venous hemodialysis using high cutoff dialyzer versus continuous veno-venous hemodiafiltration using high-flux dialyzer: a prospective randomized controlled trial

Variable Control arm CVVHDF, n = 33 Intervention arm CVVHD-HCO, n = 35 p value
Age, years 67 [51,74.5] 68 [57,74.0] 0.626
Males 26 (78.8%) 18 (51.4%) 0.180
Actual body weight, kg 80 [72,100] 80 [70,90] 0.341
Height, cm 174.70 ± 10.58 170.83 ± 9.16 0.113
BMI 26 [24, 30] 27 [24, 30] 0.873
APACHE II score 29.27 ± 7.27 29.60 ± 8.11 0.861
SOFA score 9.15 ± 3.57 10.09 ± 3.88 0.305
SAPS II score 56.27 ± 14.29 57.43 ± 14.63 0.743
Creatinine (µmol/l) 240 [170,413] 188 [129,266] 0.031
Urea (mmol/l) 19.90 ± 8.80 19.14 ± 8.99 0.728
urine output during first 24 h (ml) 530 ± 752 518 ± 602 0.941
Admission diagnosis    
 Sepsis 9 (27.3%) 11 (31.4%)  
 Pneumonia 3 (9.1%) 3 (8.6%)  
 ARDS 3 (9.1%) 4 (11.4%)  
 AKI 2 (6.1%) 3 (8.6%)  
 Hemorrhage 4 (12.1%) 1 (2.9%)  
 Cardiac 4 (12.1%) 5 (14.3%)  
 Rhabdomyolysis 2 (6.1%) 0 (0%)  
 Pancreatitis 1 (3.0%) 2 (5.7%)  
 Liver failure 1 (3.0%) 5 (14.3%)  
 Other 4 (12.1%) 1 (2.9%)  
Systolic BP, mmHg 108.33 ± 20.94 108.29 ± 20,04 0.992
MAP mmHg 70 [62,78.5] 72 [63,80] 0.961
Mechanical ventilation 24 (72.7%) 33 (94.3%) 0.16
Vasopressor 23 (69.7%) 32 (91.4%) 0.23
Pre-existing diseases    
 Congestive heart failure NYHA IV 6 (18.2%) 8 (22.9%) 0.634
 Pre-existing immunosuppression 9 (27.3%) 17 (48.6%) 0.71
 Liver cirrhosis 7 (21.2%) 10 (28.6%) 0.484
 History of malignancy 7 (21.2%) 11 (31.4%) 0.34
 Chronic pulmonary disease 3 (9.1%) 8 (22.9%) 0.123
Indication for RRT    
 Metabolic acidosis 5 (15.2%) 12 (34.3%) 0.069
 Pulmonary edema 12 (36.4%) 15 (42.9%) 0.584
 Hyperpotassemia 8 (24.2%) 7 (20%) 0.673
 Anuria (< 100 ml/d) 26 (78.8%) 25 (71.4%) 0.484
 Uremia 20 (60%) 13 (37.1%) 0.53
Main reason for AKI    
 Septic 13 (39.4%) 19 (54.3%)  
 Postrenal 0 (0%) 0 (0%)  
 Cardiorenal 4 (12.1%) 5 (14.3%)  
 Toxic 3 (9.1%) 0 (0%)  
 Hypovolemia 6 (18.2%) 3 (8.6%)  
 Rhabdomyolysis 3 (9.1%) 0 (0%)  
 Hepatorenal 2 (6.1%) 5 (14.3%)  
 Other 2 (6.1%) 3 (8.6%)  
  1. Data presented as n (%), mean ± standard deviation or median [25th, 75th quantile]
  2. BMI body mass index, APACHE II acute physiology and chronic health evaluation II, SOFA sequential organ failure assessment, SAPS II simplified acute physiology score II, ARDS Acute Respiratory Distress Syndrome, AKI acute kidney injury, BP blood pressure, MAP mean arterial blood pressure, RRT renal replacement therapy, CVVHDF continuous veno-venous hemodiafiltration, CVVHD-HCO continuous veno-venous hemodialysis using high cutoff filter