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Table 3 Correlations between demographics, clinical data and muscle parameters measured in the ICU with physical function at hospital discharge

From: Acute skeletal muscle wasting and dysfunction predict physical disability at hospital discharge in patients with critical illness

Variable

Muscle, Physical Function and Frailty assessed at Hospital Discharge, rs (p = 0.05)

Muscle power (10% BW)

5 × STS

ICU-AW

4-m gait speed

6 MWT

CFS

Age

− 0.543 (p = 0.001)

0.822 (p < 0.001)

0.269 (p = 0.118)

− 0.629 (p < 0.001)

− 0.596 (p < 0.001)

0.554 (p < 0.001)

BMI

0.096 (p = 0.597)

0.386 (p = 0.042)

− 0.285 (p = 0.097)

− 0.355 (p = 0.054)

− 0.210 (p = 0.219)

0.093 (p = 0.567)

CCI

− 0.006 (p = 0.973)

0.369 (p = 0.053)

0.137 (p = 0.431)

− 0.269 (p = 0.151)

− 0.359 (p = 0.032)

0.340 (p = 0.032)

SOFA

− 0.353 (p = 0.044)

− 0.352 (p = 0.07)

0.400 (p = 0.017)

0.262 (p = 0.162)

0.144 (p = 0.401)

− 0.219 (p = 0.174)

ICU LOS

0.090 (p = 0.618)

− 0.262 (p = 0.178)

0.348 (p = 0.041)

0.324 (p = 0.081)

0.028 (p = 0.872)

0.155 (p = 0.339)

Hospital LOS

0.109 (p = 0.545)

− 0.323 (p = 0.094)

0.440 (p = 0.008)

0.433 (p = 0.017)

0.061 (p = 0.722)

− 0.026 (p = 0.872)

RF mT (day 1)

0.248 (p = 0.160)

− 0.145 (p = 0.461)

− 0.308 (p = 0.072)

0.002 (p = 0.993)

0.059 (p = 0.732)

− 0.152 (p = 0.349)

Delta RF mT

0.112 (p = 0.534)

− 0.178 (p = 0.366)

− 0.272 (p = 0.114)

− 0.082 (p = 0.667)

− 0.079 (p = 0.646)

0.047 (p = 0.775)

RF CSA (day 1)

0.379 (p = 0.029)

− 0.230 (p = 0.248)

− 0.239 (p = 0.166)

0.131 (p = 0.491)

0.211 (p = 0.217)

− 0.239 (p = 0.138)

Delta RF CSA

− 0.159 (p = 0.375)

0.123 (p = 0.532)

− 0.181 (p = 0.297)

− 0.261 (p = 0.163)

− 0.105 (p = 0.541)

− 0.003 (p = 0.983)

RF EI (day 1)

− 0.480 (p = 0.005)

0.462 (p = 0.013)

0.337 (p = 0.048)

− 0.324 (p = 0.081)

− 0.295 (p = 0.080)

0.460 (p = 0.003)

Delta RF EI

0.150 (p = 0.406)

− 0.306 (p = 0.110)

− 0.214 (p = 0.218)

0.280 (p = 0.134)

0.190 (p = 0.268)

− 0.139 (p = 0.392)

PFIT-s*

0.670 (p < 0.001)

− 0.447 (p = 0.019)

− 0.640 (p < 0.001)

0.255 (p = 0.191)

0.648 (p < 0.001)

− 0.763 (p < 0.001)

MRC-ss*

0.333 (p = 0.090)

− 0.409 (p = 0.047)

− 0.626 (p < 0.001)

0.071 (p = 0.731)

0.429 (p = 0.018)

− 0.478 (p = 0.006)

Handgrip*

0.712 (p < 0.001)

− 0.416 (p = 0.001)

− 0.649 (p < 0.001)

0.167 (p = 0.447)

0.365 (p = 0.073)

− 0.489 (p = 0.011)

RF HHD*

0.837 (p < 0.001)

− 0.396 (p = 0.076)

− 0.597 (p = 0.003)

0.122(p = 0.589)

0.443 (p = 0.034)

− 0.551 (p = 0.005)

Muscle power (10% BW)*

0.819 (p < 0.001)

− 0.386 (p = 0.076)

− 0.541 (p = 0.005)

0.164 (p = 0.456)

0.384 (p = 0.058)

− 0.622 (p = 0.001)

  1. Ultrasound images analyzed as baseline (day of ICU admission) and change in TA from day 1 to day 7 (delta). Data are displayed as Spearman Rho tests presented as correlation coefficient with p value
  2. *Measured at ICU discharge, “Delta” represents the percentage change in muscle mT, CSA and EI from day 1 to day 7
  3. CCI = Charlson comorbidity index; SOFA = sequential organ failure assessment; MRC-ss = Medical Research Council-sum score; RF = rectus femoris muscle; HHD = handheld dynamometry; SPPB = short performance physical battery; 5 × STS = five time sit-to-stand test; 6 MWT = six-minute walk test; mT = muscle layer thickness; CSA = cross-sectional; EI = echo-intensity; BW = body weight