|
Variable
|
Muscle, Physical Function and Frailty assessed at Hospital Discharge, rs (p = 0.05)
|
|---|
|
Muscle power (10% BW)
|
5 × STS
|
ICU-AW
|
4-m gait speed
|
6 MWT
|
CFS
|
|---|
|
Age
|
− 0.543 (p = 0.001)
|
0.822 (p < 0.001)
|
0.269 (p = 0.118)
|
− 0.629 (p < 0.001)
|
− 0.596 (p < 0.001)
|
0.554 (p < 0.001)
|
|
BMI
|
0.096 (p = 0.597)
|
0.386 (p = 0.042)
|
− 0.285 (p = 0.097)
|
− 0.355 (p = 0.054)
|
− 0.210 (p = 0.219)
|
0.093 (p = 0.567)
|
|
CCI
|
− 0.006 (p = 0.973)
|
0.369 (p = 0.053)
|
0.137 (p = 0.431)
|
− 0.269 (p = 0.151)
|
− 0.359 (p = 0.032)
|
0.340 (p = 0.032)
|
|
SOFA
|
− 0.353 (p = 0.044)
|
− 0.352 (p = 0.07)
|
0.400 (p = 0.017)
|
0.262 (p = 0.162)
|
0.144 (p = 0.401)
|
− 0.219 (p = 0.174)
|
|
ICU LOS
|
0.090 (p = 0.618)
|
− 0.262 (p = 0.178)
|
0.348 (p = 0.041)
|
0.324 (p = 0.081)
|
0.028 (p = 0.872)
|
0.155 (p = 0.339)
|
|
Hospital LOS
|
0.109 (p = 0.545)
|
− 0.323 (p = 0.094)
|
0.440 (p = 0.008)
|
0.433 (p = 0.017)
|
0.061 (p = 0.722)
|
− 0.026 (p = 0.872)
|
|
RF mT (day 1)
|
0.248 (p = 0.160)
|
− 0.145 (p = 0.461)
|
− 0.308 (p = 0.072)
|
0.002 (p = 0.993)
|
0.059 (p = 0.732)
|
− 0.152 (p = 0.349)
|
|
Delta RF mT
|
0.112 (p = 0.534)
|
− 0.178 (p = 0.366)
|
− 0.272 (p = 0.114)
|
− 0.082 (p = 0.667)
|
− 0.079 (p = 0.646)
|
0.047 (p = 0.775)
|
|
RF CSA (day 1)
|
0.379 (p = 0.029)
|
− 0.230 (p = 0.248)
|
− 0.239 (p = 0.166)
|
0.131 (p = 0.491)
|
0.211 (p = 0.217)
|
− 0.239 (p = 0.138)
|
|
Delta RF CSA
|
− 0.159 (p = 0.375)
|
0.123 (p = 0.532)
|
− 0.181 (p = 0.297)
|
− 0.261 (p = 0.163)
|
− 0.105 (p = 0.541)
|
− 0.003 (p = 0.983)
|
|
RF EI (day 1)
|
− 0.480 (p = 0.005)
|
0.462 (p = 0.013)
|
0.337 (p = 0.048)
|
− 0.324 (p = 0.081)
|
− 0.295 (p = 0.080)
|
0.460 (p = 0.003)
|
|
Delta RF EI
|
0.150 (p = 0.406)
|
− 0.306 (p = 0.110)
|
− 0.214 (p = 0.218)
|
0.280 (p = 0.134)
|
0.190 (p = 0.268)
|
− 0.139 (p = 0.392)
|
|
PFIT-s*
|
0.670 (p < 0.001)
|
− 0.447 (p = 0.019)
|
− 0.640 (p < 0.001)
|
0.255 (p = 0.191)
|
0.648 (p < 0.001)
|
− 0.763 (p < 0.001)
|
|
MRC-ss*
|
0.333 (p = 0.090)
|
− 0.409 (p = 0.047)
|
− 0.626 (p < 0.001)
|
0.071 (p = 0.731)
|
0.429 (p = 0.018)
|
− 0.478 (p = 0.006)
|
|
Handgrip*
|
0.712 (p < 0.001)
|
− 0.416 (p = 0.001)
|
− 0.649 (p < 0.001)
|
0.167 (p = 0.447)
|
0.365 (p = 0.073)
|
− 0.489 (p = 0.011)
|
|
RF HHD*
|
0.837 (p < 0.001)
|
− 0.396 (p = 0.076)
|
− 0.597 (p = 0.003)
|
0.122(p = 0.589)
|
0.443 (p = 0.034)
|
− 0.551 (p = 0.005)
|
|
Muscle power (10% BW)*
|
0.819 (p < 0.001)
|
− 0.386 (p = 0.076)
|
− 0.541 (p = 0.005)
|
0.164 (p = 0.456)
|
0.384 (p = 0.058)
|
− 0.622 (p = 0.001)
|
- Ultrasound images analyzed as baseline (day of ICU admission) and change in TA from day 1 to day 7 (delta). Data are displayed as Spearman Rho tests presented as correlation coefficient with p value
- *Measured at ICU discharge, “Delta” represents the percentage change in muscle mT, CSA and EI from day 1 to day 7
- CCI = Charlson comorbidity index; SOFA = sequential organ failure assessment; MRC-ss = Medical Research Council-sum score; RF = rectus femoris muscle; HHD = handheld dynamometry; SPPB = short performance physical battery; 5 × STS = five time sit-to-stand test; 6 MWT = six-minute walk test; mT = muscle layer thickness; CSA = cross-sectional; EI = echo-intensity; BW = body weight
