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Table 3 Correlations between demographics, clinical data and muscle parameters measured in the ICU with physical function at hospital discharge

From: Acute skeletal muscle wasting and dysfunction predict physical disability at hospital discharge in patients with critical illness

Variable Muscle, Physical Function and Frailty assessed at Hospital Discharge, rs (p = 0.05)
Muscle power (10% BW) 5 × STS ICU-AW 4-m gait speed 6 MWT CFS
Age − 0.543 (p = 0.001) 0.822 (p < 0.001) 0.269 (p = 0.118) − 0.629 (p < 0.001) − 0.596 (p < 0.001) 0.554 (p < 0.001)
BMI 0.096 (p = 0.597) 0.386 (p = 0.042) − 0.285 (p = 0.097) − 0.355 (p = 0.054) − 0.210 (p = 0.219) 0.093 (p = 0.567)
CCI − 0.006 (p = 0.973) 0.369 (p = 0.053) 0.137 (p = 0.431) − 0.269 (p = 0.151) − 0.359 (p = 0.032) 0.340 (p = 0.032)
SOFA − 0.353 (p = 0.044) − 0.352 (p = 0.07) 0.400 (p = 0.017) 0.262 (p = 0.162) 0.144 (p = 0.401) − 0.219 (p = 0.174)
ICU LOS 0.090 (p = 0.618) − 0.262 (p = 0.178) 0.348 (p = 0.041) 0.324 (p = 0.081) 0.028 (p = 0.872) 0.155 (p = 0.339)
Hospital LOS 0.109 (p = 0.545) − 0.323 (p = 0.094) 0.440 (p = 0.008) 0.433 (p = 0.017) 0.061 (p = 0.722) − 0.026 (p = 0.872)
RF mT (day 1) 0.248 (p = 0.160) − 0.145 (p = 0.461) − 0.308 (p = 0.072) 0.002 (p = 0.993) 0.059 (p = 0.732) − 0.152 (p = 0.349)
Delta RF mT 0.112 (p = 0.534) − 0.178 (p = 0.366) − 0.272 (p = 0.114) − 0.082 (p = 0.667) − 0.079 (p = 0.646) 0.047 (p = 0.775)
RF CSA (day 1) 0.379 (p = 0.029) − 0.230 (p = 0.248) − 0.239 (p = 0.166) 0.131 (p = 0.491) 0.211 (p = 0.217) − 0.239 (p = 0.138)
Delta RF CSA − 0.159 (p = 0.375) 0.123 (p = 0.532) − 0.181 (p = 0.297) − 0.261 (p = 0.163) − 0.105 (p = 0.541) − 0.003 (p = 0.983)
RF EI (day 1) − 0.480 (p = 0.005) 0.462 (p = 0.013) 0.337 (p = 0.048) − 0.324 (p = 0.081) − 0.295 (p = 0.080) 0.460 (p = 0.003)
Delta RF EI 0.150 (p = 0.406) − 0.306 (p = 0.110) − 0.214 (p = 0.218) 0.280 (p = 0.134) 0.190 (p = 0.268) − 0.139 (p = 0.392)
PFIT-s* 0.670 (p < 0.001) − 0.447 (p = 0.019) − 0.640 (p < 0.001) 0.255 (p = 0.191) 0.648 (p < 0.001) − 0.763 (p < 0.001)
MRC-ss* 0.333 (p = 0.090) − 0.409 (p = 0.047) − 0.626 (p < 0.001) 0.071 (p = 0.731) 0.429 (p = 0.018) − 0.478 (p = 0.006)
Handgrip* 0.712 (p < 0.001) − 0.416 (p = 0.001) − 0.649 (p < 0.001) 0.167 (p = 0.447) 0.365 (p = 0.073) − 0.489 (p = 0.011)
RF HHD* 0.837 (p < 0.001) − 0.396 (p = 0.076) − 0.597 (p = 0.003) 0.122(p = 0.589) 0.443 (p = 0.034) − 0.551 (p = 0.005)
Muscle power (10% BW)* 0.819 (p < 0.001) − 0.386 (p = 0.076) − 0.541 (p = 0.005) 0.164 (p = 0.456) 0.384 (p = 0.058) − 0.622 (p = 0.001)
  1. Ultrasound images analyzed as baseline (day of ICU admission) and change in TA from day 1 to day 7 (delta). Data are displayed as Spearman Rho tests presented as correlation coefficient with p value
  2. *Measured at ICU discharge, “Delta” represents the percentage change in muscle mT, CSA and EI from day 1 to day 7
  3. CCI = Charlson comorbidity index; SOFA = sequential organ failure assessment; MRC-ss = Medical Research Council-sum score; RF = rectus femoris muscle; HHD = handheld dynamometry; SPPB = short performance physical battery; 5 × STS = five time sit-to-stand test; 6 MWT = six-minute walk test; mT = muscle layer thickness; CSA = cross-sectional; EI = echo-intensity; BW = body weight
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