Table 2 Demographics and outcomes of the sepsis cohort and comparisons between 30-day non-survivors and survivors
From: Circulating bioactive adrenomedullin as a marker of sepsis, septic shock and critical illness
Sepsis cohort | Non-survivors | Survivors | p value | |
|---|---|---|---|---|
Number, n (% of Sepsis cohort) | 632 (100) | 174 (27.5) | 458 (72.5) | |
Age in years, median (IQR) | 69 (61–76) | 73 (66–79) | 68 (59–75) | < 0.001 |
Female sex, n (%) | 251 (39.7) | 61 (35.1) | 190 (41.5) | 0.17 |
Body mass index (n = 588), median (IQR) | 26.6 (22.9–30.7) | 26.7 (23.3–31.2) | 26.3 (21.8–30.5) | 0.11 |
Comorbidities | ||||
None of those listed below, n (%) | 173 (27.4) | 46 (26.4) | 127 (27.7) | 0.74 |
Cardiovascular disease, n (%) | 313 (49.5) | 87 (50) | 226 (49) | 0.95 |
Respiratory disease, n (%) | 156 (24.7) | 47 (27) | 109 (23.8) | 0.46 |
Hepatic disease, n (%) | 32 (5) | 12 (6.9) | 20 (4.4) | 0.27 |
Renal disease, n (%) | 63 (10.0) | 18 (10.3) | 45 (9.8) | 0.96 |
Cancer, n (%) | 109 (17.3) | 37 (21.3) | 72 (15.7) | 0.13 |
Haematological disease, n (%) | 47 (7.4) | 17 (9.8) | 30 (6.6) | 0.23 |
Immunosuppression, n (%) | 126 (19.9) | 41 (23.6) | 85 (18.6) | 0.20 |
Diabetes, n (%) | 167 (26.4) | 40 (23.0) | 127 (27.7) | 0.27 |
Modified Charlson comorbidity index, median (IQR) | 1 (0–2) | 2 (0–2) | 1 (0–2) | 0.54 |
Department of origin | ||||
Emergency department/out of hospital, n (%) | 276 (43.7) | 62 (35.6) | 214 (46.7) | 0.012 |
Hospital ward, n (%) | 282 (44.6) | 87 (50) | 195 (42.6) | 0.094 |
Intermediate, n (%) | 32 (5.1) | 13 (7.5) | 19 (4.1) | 0.089 |
Operating room/postoperative ward, n (%) | 42 (6.6) | 12 (6.9) | 30 (6.6) | 0.88 |
Organ dysfunction and illness severity on ICU admission | ||||
SAPS3 score, median (IQR) | 66 (57–77) | 76 (66–82) | 63 (56–73) | < 0.001 |
SAPS3 EMR30-day, median (IQR) | 29.9 (14.8–53) | 50.9 (29.9–62.7) | 24.2 (13.5–44.5) | < 0.001 |
SOFA score, median (IQR) | 7 (5–10) | 9 (6–11) | 7 (5–9) | < 0.001 |
Cardiovascular SOFA score (n = 625), median (IQR) | 3 (0–4) | 3 (1–4) | 3 (0–4) | 0.037 |
Septic shock, n (%) | 267 (42.2) | 82 (47.1) | 185 (40.4) | 0.15 |
Outcomes | ||||
ICU length of stay in days, median (IQR) | 2.5 (1.1–5.5) | 2.7 (1.2–6.2) | 2.4 (1–4.9) | 0.16 |
CRRT use during ICU stay, n (%) | 96 (15.2) | 38 (21.8) | 58 (12.7) | 0.006 |
Biomarkers | ||||
bio-ADM pg/mL, median (IQR) | 74 (42–145) | 93 (51–173) | 70 (39–131) | < 0.001 |
bio-ADM > 70 pg/mL, n (%) | 333 (52.7) | 104 (59.8) | 229 (50) | 0.035 |
Lactate (n = 626) mmol/L, median (IQR) | 2.8 (1.5–4.9) | 3.3 (1.7–5.7) | 2.5 (1.4–4.6) | 0.002 |
CRP (n = 600) mg/L, median (IQR) | 113 (35–241) | 143 (47–238) | 102 (32–242) | 0.13 |