Table 1 Demographics and outcomes of the ICU population and a comparison between the sepsis and non-sepsis cohorts
From: Circulating bioactive adrenomedullin as a marker of sepsis, septic shock and critical illness
ICU population | Sepsis cohort | Non-sepsis cohort | p value | |
|---|---|---|---|---|
Number, n (% of ICU population) | 1867 (100) | 632 (33.9) | 1235 (66.1) | |
Age in years, median (IQR) | 67 (54–75) | 69 (61–76) | 65 (49.5–73) | < 0.001 |
Female sex, n (%) | 738 (39.5) | 251 (39.7) | 487 (39.4) | 0.95 |
Department of origin | ||||
Emergency department/out of hospital, n (%) | 896 (48) | 276 (43.7) | 620 (50.2) | 0.008 |
Hospital ward, n (%) | 604 (32.4) | 282 (44.6) | 322 (26.1) | < 0.001 |
Intermediate, n (%) | 50 (2.7) | 32 (5.1) | 18 (1.5) | < 0.001 |
Operating room/postoperative ward, n (%) | 317 (17) | 42 (6.6) | 275 (22.3) | < 0.001 |
Organ dysfunction and illness severity on ICU admission | ||||
SAPS3 score, median (IQR) | 59 (47–71) | 66 (57–77) | 54 (43–67) | < 0.001 |
SAPS3 EMR30-day, median (IQR) | 17.6 (5.2–40.3) | 29.9 (14.8–53) | 11.1 (3.1–31.9) | < 0.001 |
SOFA score, median (IQR) | 6 (3–9) | 7 (5–10) | 4 (1–8) | < 0.001 |
Cardiovascular SOFA score (n = 1836), median (IQR) | 1 (0–3) | 3 (0–4) | 1 (0–3) | < 0.001 |
Outcomes | ||||
ICU mortality, n (%) | 208 (11.1) | 86 (13.6) | 122 (9.9) | 0.019 |
30-day mortality, n (%) | 402 (21.5) | 174 (27.5) | 228 (18.5) | < 0.001 |
1-year mortality, n (%) | 622 (33.3) | 261 (41.3) | 361 (29.2) | < 0.001 |
ICU length of stay in days, median (IQR) | 1.6 (0.8–3.6) | 2.5 (1.1–5.5) | 1.1 (0.7–2.7) | < 0.001 |
CRRT use during ICU stay, n (%) | 169 (9) | 96 (15.2) | 73 (5.9) | < 0.001 |
bio-ADM | ||||
bio-ADM pg/mL, median (IQR) | 40 (21–86) | 74 (42–145) | 29 (18–56) | < 0.001 |
bio-ADM> 70 pg/mL, n (%) | 564 (30.2) | 333 (52.7) | 231 (18.7) | < 0.001 |