Table 4 The percentage of PD-L1+ NK cells, SOFA score, the combination of them and NK counts, MFI of CD28 in NK, and APACHE II score for predicting 28-day mortality
Variables | ROC curve | Sensitivity (%) | Specificity (%) | Youden index (%) | PPV (%) | NPV (%) | ||
|---|---|---|---|---|---|---|---|---|
AUC (95% CI) | Best cutoff | p | ||||||
APACHE II score | 0.678 (0.583–0.763) | 18 | 0.001 | 70.00 | 62.20 | 32.20 | 40.39 | 85.00 |
SOFA score | 0.727 (0.635–0.807) | 8 | < 0.001 | 60.00 | 71.95 | 31.95 | 43.91 | 83.10 |
NK counts (× 109/L) | 0.670 (0.574–0.755) | ≤ 0.029 | 0.003 | 60.00 | 74.39 | 34.39 | 41.16 | 83.56 |
MFI of CD28 in NK | 0.630 (0.534–0.719) | ≤ 5390 | 0.046 | 60.00 | 76.38 | 36.83 | 48.65 | 84.00 |
NK PD-L1 (%) | 0.655 (0.559–0.742) | 5.58 | 0.004 | 96.67 | 32.93 | 29.59 | 34.53 | 96.43 |
SOFA+NK PD-L1 model | 0.808 (0.723–0.876) | 0.1241 | < 0.001 | 90.00 | 58.54 | 48.54 | 44.27 | 94.12 |