Table 2 Results from multivariate linear regression analysis from bench model testing data examining the independent contribution of categorized endotracheal tube (ETT) size (0 [ETT 3 mm] to 5 [ETT 8 mm]), categorized compliance (1 [normal] to 5 [severely low]), categorized resistance (1 [no resistance] to 3 [high]), categorized tidal volume (in mL/kg) for VC ventilation or pressure above PEEP for PC ventilation, and categorized inspiratory time (1 [− 20% compared to age-appropriate] to 3 [+ 20% compared to age-appropriate]) to the percentage of mechanical energy generated by the ventilator (calculated by [(0.098 × (Vt × kg− 1) × (PIP – [(Pplat – PEEP)/2])] with ventilator parameters measured at the Y – piece) that is delivered to the lungs (measured by integrating the dynamic pressure – volume curve in the test lung)
From: Energy transmission in mechanically ventilated children: a translational study
|  | β | 95% CI | P value |
|---|---|---|---|
A: Percentage of energy dissipated to the lung during VC ventilation | |||
 ETT size (mm) | − 1.391 | − 1.908; − 0.0874 | < 0.001 |
 Vt (mL/kg) | 3.294 | 2.592;3.997 | < 0.001 |
 Compliance (mL/cmH2O/kg) | 13.326 | 12.931;13.720 | < 0.001 |
 Resistance | − 8.061 | − 8.722; − 7.401 | < 0.001 |
 Inspiratory time (s) | 2.754 | 2.078;3.430 | < 0.001 |
 Inspiratory flow (L/min) | − 0.041 | − 0.092;0.009 | 0.110 |
B: Percentage of energy dissipated to the lung during PC ventilation | |||
 ETT size (mm) | 0.090 | − 0.299;0.478 | 0.650 |
 Pressure above PEEP (cmH2O) | 0.602 | 0.444;0.761 | < 0.001 |
 Compliance (mL/cmH2O/kg) | 11.130 | 10.662;11.598 | < 0.001 |
 Resistance | −10.206 | − 11.000; − 9.413 | < 0.001 |
 Inspiratory time (s) | 4.322 | 3.528–5.115 | < 0.001 |