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Table 2 Blood tests of the 79 patients and comparisons between patients treated with tocilizumab + Std therapy and those treated with Std therapy alone

From: Efficacy of tocilizumab in patients with COVID-19 ARDS undergoing noninvasive ventilation

  Overall population Tocilizumab + Std therapy Std therapy p value
pH, mean ± SD
 At admission 7.45 ± 0.05 7.46 ± 0.5 7.45 ± 0.05 0.66
 At 72 h 7.44 ± 0.07 7.44 ± 0.03 7.43 ± 0.1 0.07
 At 7 days 7.45 ± 0.04 7.44 ± 0.04 7.46 ± 0.03 0.05
pO2 (mmHg), mean ± SD
 At admission 67.4 ± 20.3 67.1 ± 16.9 67.7 ± 23.8 0.66
 At 72 h 85.7 ± 29.9 85.2 ± 18.5 86.1 ± 39.8 0.4
 At 7 days 100.8 ± 42.7 104 ± 42.9 95.9 ± 43.1 0.5
pCO2 (mmHg), mean ± SD
 At admission 36.5 ± 6.2 36.9 ± 5.5 36 ± 7 0.3
 At 72 h 40.7 ± 11.1 40.2 ± 4.8 41.4 ± 15.6 0.4
 At 7 days 40 ± 5.9 39.4 ± 4.9 40.8 ± 7.2 0.5
pO2/FiO2 ratio (mmHg), mean ± SD
 At admission 120.1 ± 41.6 117.8 ± 34.4 122.8 ± 48.9 0.8
 At 72 h 155.6 ± 78.6 143.8 ± 53 169.6 ± 100.2 0.6
 At 7 days 191 ± 86.8 186.2 ± 78.5 198.1 ± 99.3 0.8
Leukocytes (109/L), mean ± SD
 At admission 6.42 ± 2.68 6.2 ± 2.7 7.2 ± 2.4 0.1
 At 72 h 8.1 ± 3 8.2 ± 3.2 7.6 ± 2.2 0.9
 At 7 days 8.3 ± 3.9 8.2 ± 4.1 8.5 ± 3.3 0.8
Neutrophils (109 / L), mean ± SD
 At admission 4.77 ± 1.89 4.6 ± 1.9 5.8 ± 1.7 0.07
 At 72 h 6.8 ± 3 6.9 ± 3.1 6.4 ± 2.6 0.6
 At 7 days 6.5 ± 4.2 6.4 ± 4.4 6.7 ± 3.6 0.7
Lymphocytes (109 / L), mean ± SD
 At admission 0.8 ± 0.35 0.8 ± 0.4 0.9 ± 0.3 0.6
 At 72 h 0.8 ± 0.5 0.8 ± 0.5 0.8 ± 0.5 0.9
 At 7 days 1.2 ± 0.5 1.2 ± 0.6 1.2 ± 0.4 0.8
D-dimer (ng/dl), mean ± SD
 At admission 774.5 ± 917 775 ± 957.8 NA
 At 72 h 6388.2 ± 8143.4 5388.3 ± 8143.4 NA
 At 7 days 2602.7 ± 2861.1 2602.7 ± 2861.1 NA
Ferritin (ng/ml), mean ± SD
 At admission 688.9 ± 683.6 652.9 ± 721.6 NA
 At 72 h 1758.9 ± 1545.7 1906 ± 1603 830 ± 415 0.3
 At 7 days 1137.9 ± 881.6 1194 ± 903.4 577 ± 349.3 0.4
CRP (mg/dl), mean ± SD
 At admission 11.9 ± 7.2 11.2 ± 7 14.3 ± 7.6 0.2
 At 72 h 8.5 ± 9.5 6.4 ± 6.5 17.2 ± 14.9 0.02
 At 7 days 4.5 ± 8.4 2.3 ± 4.9 13.3 ± 13.5 0.001
LDH (U/l), mean ± SD
 At admission 687.7 ± 244.6 700.5 ± 250.5 534 ± 24.4 0.2
 At 72 h 745.3 ± 320.3 757 ± 314 701 ± 361.7 0.2
 At 7 days 682.3 ± 326.5 693.1 ± 334.9 633.3 ± 309.1 0.7
IL-6 (pg/ml), mean ± SD
 At admission 147.2 ± 180.4 145.9 ± 190.1 NA
 At 72 h 656.4 ± 878.9 656.4 ± 878.9 NA
 At 7 days 623.2 ± 1217.4 623.2 ± 1217.4 NA
  1. Std therapy standard therapy, CRP C-reactive protein, LDH lactate dehydrogenase, IL-6 interleukin-6, NA not applicable