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Table 1 Effects of intra-arrest epinephrine on cerebrovascular and systemic hemodynamics by dose

From: Epinephrine’s effects on cerebrovascular and systemic hemodynamics during cardiopulmonary resuscitation

  Dose 1 (n = 20)   Dose 2 (n = 20)   Dose 3 (n = 9)   Dose 4 (n = 7)   Dose 5 (n = 4)  
  Effect size p Effect size p Effect size p Effect size p Effect size p
(Δ, % Baseline)
Invasive rCBF + 8.2 [1.1, 22.4] 0.004* + 4.3 [1.3, 8.8] 0.002* + 3.5 [1.1, 8.0] 0.047 + 0.9 [0.4, 2.3] 0.156 − 0.0 [− 0.7, 0.4] 0.875
Non-invasive rCBF + 17.3 [4.6, 23.6] 0.001* + 5.6 [0.4, 16.1] 0.015 + 6.7 [0.5, 12.2] 0.156 + 3.8 [− 2.3, 8.1] 0.438 − 3.7 [− 9.1, 3.6] 0.750
rPbtO2 + 6.4 [0.6, 18.7] 0.001* + 0.3 [− 2.7, 5.0] 0.494 − 0.2 [− 6.1, 1.0] 0.426 − 0.2 [− 2.6, 0.3] 0.578 + 0.1 [− 1.1, 0.5] 0.875
rStO2 + 7.9 [4.1, 12.6] < 0.001* + 3.4 [0.4, 7.0] < 0.001* + 1.8 [− 0.8, 3.3] 0.129 − 1.1 [− 1.8, 2.0] 0.938 − 0.6 [− 2.3, 1.1] 0.625
rTHC + 3.0 [1.9, 6.4] 0.001* + 1.1 [0.3, 2.0] 0.007* − 0.4 [− 2.3, 2.0] > 0.999 + 0.6 [− 0.5, 1.0] 0.578 − 0.7 [− 1.5, − 0.4] 0.125
r [HbO2] + 11.0 [5.9, 16.1] < 0.001* + 6.0 [0.8, 9.6] < 0.001* + 1.7 [− 1.8, 4.4] 0.250 − 0.9 [− 1.6, 3.3] 0.938 − 0.9 [− 3.1, 1.0] 0.625
r [Hb] − 2.9 [− 12.1, 0.3] 0.006* − 2.7 [− 6.2, 0.4] 0.012 − 1.4 [− 4.1, 0.2] 0.098 + 0.5 [− 1.2, 1.4] 0.938 − 0.8 [− 1.9, − 0.2] 0.250
(Δ, mmHg)
SBP + 17.6 [8.4, 52.0] < 0.001* + 16.5 [6.4, 26.0] < 0.001* + 21.0 [1.8, 34.7] 0.027 + 9.7 [− 3.5, 18.1] 0.156 − 1.6 [− 3.2, 4.3] 0.875
DBP + 9.4 [5.0, 13.5] < 0.001* + 5.5 [3.7, 9.0] < 0.001* + 2.8 [1.1, 6.0] 0.012* + 2.4 [1.2, 5.4] 0.016* + 1.3 [− 0.7, 2.9] 0.625
CPP + 8.2 [3.9, 11.7] < 0.001* + 4.5 [2.7, 8.2] < 0.001* + 3.8 [0.9, 6.1] 0.020 + 2.4 [1.2, 5.2] 0.016 + 1.3 [− 0.7, 2.7] 0.625
  1. Effect size reported as median [interquartile range]
  2. Abbreviations: Δ change in value, n sample size, rCBF relative cerebral blood flow, rPbtO2 relative partial pressure of oxygen in brain tissue, rStO2 relative cerebral tissue oxygen saturation, rTHC relative total hemoglobin concentration, r [HbO2] relative concentration of oxy-hemoglobin, r [Hb] relative concentration of deoxy-hemoglobin, SBP systolic aortic blood pressure, DBP diastolic aortic blood pressure, CPP coronary perfusion pressure
  3. *Adjusted p < 0.05 after false discovery rate correction for repeated comparisons