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Table 4 Factors associated with severity of COVID-19

From: Longitudinal changes of inflammatory parameters and their correlation with disease severity and outcomes in patients with COVID-19 from Wuhan, China

 

Univariate logistic regression

Multivariate logistic regression

OR

95% CI

P value

OR

95% CI

P value

Age  >65 years

1.81

1.18–2.78

0.006

1.81

1.08–3.03

0.024

Males

1.36

0.89–2.08

0.152

0.69

0.41–1.16

0.162

Shortness of breath

1.92

1.25–2.94

0.003

1.48

0.91–2.42

0.115

Laboratory findings

 White blood cell count > 10 × 10^9/L

7.53

3.87–14.65

< 0.001

–

–

–

 Neutrophil count > 7 × 10^9/L

7.60

4.21–13.74

< 0.001

2.31

1.12–4.77

0.024

 Lymphocyte count < 0.6 × 10^9/L

3.55

2.11–5.99

< 0.001

1.23

0.66–2.29

0.522

 Hemoglobin > 110 g/L

1.29

0.65–2.54

0.468

–

–

–

 Platelet count < 100 × 10^9/L

2.38

1.45–3.93

0.001

2.09

1.15–3.79

0.015

 Albumin < 30 g/L

4.11

2.36–7.16

< 0.001

1.02

0.49–2.12

0.959

 Blood bicarbonate ions < 20 mmol/L

2.89

1.69–4.92

< 0.001

1.27

0.67–2.38

0.466

 Blood urea nitrogen > 6 mmol/L

5.81

3.41–9.89

< 0.001

1.58

0.79–3.14

0.194

 Blood creatinine > 100 μmol/L

2.84

1.66–4.85

< 0.001

1.14

0.56–2.31

0.717

 Lactate dehydrogenase > 400 U/L

16.57

8.80–31.20

< 0.001

5.45

2.42–12.26

< 0.001

 High-sensitivity C-reactive protein > 90 mg/L

4.83

2.84–8.21

< 0.001

1.21

0.58–2.50

0.615

 Procalcitonin > 0.2 ng/mL

6.29

3.64–10.85

< 0.001

1.45

0.67–3.17

0.347

 Ferritin > 1000 μg/L

4.06

2.42–6.82

< 0.001

1.06

0.52–2.13

0.876

 Soluble interlukin-2 receptor > 1200 U/mL

5.20

3.06–8.86

< 0.001

1.60

0.78–3.30

0.198

 Interlukin-6 > 50 pg/mL

4.88

2.86–8.33

< 0.001

2.02

1.11–4.03

0.045

 Interlukin-8 > 25 pg/mL

2.65

1.61–4.36

< 0.001

1.10

0.61–2.00

0.749

 Interlukin-10 > 10 pg/mL

2.77

1.70–4.52

< 0.001

1.30

0.72–2.35

0.383

 Tumor necrosis factor alpha > 10 pg/mL

1.96

1.20–3.20

0.007

0.71

0.37–1.36

0.308

 hsCRP/lymphocyte > 120 × 10^9 mg

7.14

4.10–12.44

< 0.001

–

–

–